ArticleBioactive materials2026
Nanozyme-crosslinked dual-network hydrogel enables multi-stage modulation of the dysregulated repair cascade for regenerative wound healing.
Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Adult mammalian wound healing typically results in fibrosis-associated repair rather than regenerative restoration, a process that can be further exacerbated by persistent inflammation, microbial infection, and aberrant mechanotransduction. Here, we present a nanozyme-crosslinked dual-network hydrogel (GPP@VP) that enables multi-stage modulation of this dysregulated repair cascade. The hydrogel integrates a dynamic γ-polyglutamic acid (γ-PGA)/ε-poly-L-lysine (ε-PLL) ionic network with CaP@TGnase-mediated covalent crosslinking, providing mechanical robustness, injectability, and wet-tissue adhesion. Functionally, GPP@VP enables stage-associated regulation across the healing process: Ca
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