Evidence map›Paper›PMID 42381966›Full record

ArticleBioactive materials2026

Systematic discovery of immunomodulatory plant-derived nanoparticles reveals RNA-mediated macrophage reprogramming.

Dokyung Jung, Ju-Hyun Bae, Il-Young Jung, Na-Eun Kim, Jung Min Sung, Kyung-Won Doh, Minju Kim, Jiwoong Choi, Eunji Ha, Hee Jin Cho and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Dokyung JungDepartment of Molecular Medicine, Cell and Matrix Research Institute (CMRI), School of Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea.
Ju-Hyun BaeDepartment of Molecular Medicine, Cell and Matrix Research Institute (CMRI), School of Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea.
Il-Young JungDepartment of Molecular Medicine, Cell and Matrix Research Institute (CMRI), School of Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea.
Na-Eun KimDepartment of Molecular Medicine, Cell and Matrix Research Institute (CMRI), School of Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea.
Jung Min SungDepartment of Advanced Bioconvergence, CMRI, Kyungpook National University, Daegu, 41566, Republic of Korea.
Kyung-Won DohDepartment of Molecular Medicine, Cell and Matrix Research Institute (CMRI), School of Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea.
Minju KimDepartment of Molecular Medicine, Cell and Matrix Research Institute (CMRI), School of Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea.
Jiwoong ChoiDepartment of Immunology, CMRI, School of Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea.
Eunji HaDepartment of Molecular Medicine, Cell and Matrix Research Institute (CMRI), School of Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea.
Hee Jin ChoDepartment of Advanced Bioconvergence, CMRI, Kyungpook National University, Daegu, 41566, Republic of Korea.
Byung Sun MinCollege of Pharmacy, Catholic University of Daegu, 42472, Republic of Korea.
Jong Hyun KimDepartment of Biochemistry, School of Medicine, Daegu Catholic University, Daegu, 42472, Republic of Korea.
Sin-Hyeog ImDepartment of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
Moon-Chang BaekDepartment of Molecular Medicine, Cell and Matrix Research Institute (CMRI), School of Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plant-derived nanoparticles (PNPs) have emerged as a promising class of bioactive nanomaterials with intrinsic immunomodulatory properties, offering a sustainable and biocompatible alternative to synthetic delivery systems. However, their systematic exploration has been hindered by a fragmented "one-plant-one-function" research paradigm. Here, we establish a comprehensive bio-discovery platform by constructing a taxonomically diverse library of 110 PNPs. Through integrated physicochemical characterization and high-throughput functional screening, we identify

Indexed as

Bioactive nanomaterialsCancer immunotherapyMacrophage reprogrammingPlant-derived nanoparticlesRNA-Mediated immunomodulation

Identifiers

PMID42381966
PMCPMC13316234

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.