ArticleJTCVS open2026
Physically validated mitral valve models for surgical simulation: Bridging anatomy, pathology, and practice.
Article in JTCVS open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
7 authors.
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Abstract
Objective: Effective mitral valve repair remains significantly operator-dependent partially due to the lack of standardized training substrates. We aimed to develop a simplified, parametric mathematical model of the mitral valve apparatus and physically validate its ability to accurately recreate the geometry and hemodynamic function of both a healthy valve and specified pathological valves when tested in a dynamic pulse duplicator system. Methods: A parametric mathematical framework was employed to define the 3-dimensional saddle-shaped annulus and its leaflet architecture using core, clinically measurable geometric coefficients (eg, annular diameters and segment-specific leaflet lengths). Five distinct silicone valve replicas were manufactured to match the mathematical specifications: 2 healthy baselines and 3 Carpentier Type II Prolapse valve variants (P1, P2, and P3) induced by localized leaflet length adjustments. Each physical model was tested in a dynamic pulse duplicator under physiological pressure and flow conditions. Valve function, geometry and regurgitation severity were quantified using cardiac ultrasound. Results: Derived measurements from the physical valve replicas accurately matched expected anatomical ranges from patient cohorts. The healthy baseline models consistently demonstrated competent function with no regurgitation. Pathological models, generated solely by manipulating the core geometric coefficients (lengthened P-segment, increased annular diameter), consistently exhibited characteristic segmental prolapse and moderate to severe mitral regurgitation. The resulting functional metrics, including regurgitant jet severity, confirmed the predictable functional outcome driven by the specified geometric inputs. Conclusions: We present a physically validated, anatomically configurable mathematical model that demonstrates a direct and predictable link between core geometric parameters and mitral valve functional behavior. Unlike existing physical simulation platforms that rely on biological tissue, this approach provides a standardized, reproducible, and customizable platform for surgical training and in vitro testing of novel repair techniques for segmental mitral valve disease.
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