ArticleReproductive, female and child health2024
IDENTIFYING ASSOCIATIONS BETWEEN GENETIC CONDITIONS IN OFFSPRING AND PREGNANCY HEALTH COMPLICATIONS.
Article in Reproductive, female and child health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Evaluating pregnancy and neonatal outcomes in mothers with genetic disease using electronic health care records.Genetics in medicine : official journal of the American College of Medical Genetics · 2026Article
- Neonates at Risk: Understanding the Impact of High-Risk Pregnancies on Neonatal Health.Medicina (Kaunas, Lithuania) · 2025Review
- Advancing precision care in pregnancy through a treatable fetal findings list.American journal of human genetics · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Background: Prior research has identified associations between pregnancy complications and specific genetic diagnoses in offspring. Objective: The purpose of this study is to provide a broader investigation of associations between infant genetic diagnoses and pregnancy complications. Methods: Retrospective chart review of birthing parent-infant dyads born at Duke University (2013-2021) identified 236 birthing parents who had infants postnatally diagnosed with genetic diseases (exposed group) and 472 matched dyads without concern for newborn genetic disease (unexposed group). Logistic regression examined associations between pregnancy complications and genetic diseases in offspring. Results: The risk of gestational diabetes was elevated among birthing parents of infants with aneuploidy (risk ratio [RR] = 1.63; 95% confidence interval [CI]: 1.02, 2.59) when controlled for birthing parent age. The risk of preeclampsia was elevated among birthing parents of infants with imprinting conditions (RR = 3.31; 95% CI: 1.29, 8.49) when controlled for birthing parent age. The presence of any infant genetic disease was associated with an increase in placental disorders (RR = 1.98; 95% CI: 1.61, 2.43), including a 2.25-fold increase in placental infarction (RR = 2.25; 95% CI 1.72, 2.93). Conclusions: These findings provide additional evidence into relationships between genetic diseases in offspring and pregnancy complications in birthing parents and may guide identification of pregnancies that would benefit from expanded prenatal and antenatal genetic screening for earlier identification and treatment of genetic conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.