ArticleInfection and drug resistance2026
Clinical Characteristics and Risk Factors of Carbapenem-Resistant
Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Background: Carbapenem-resistant Methods: This case-control study retrospectively analyzed clinical data of 162 patients with CREC UTIs (2018-2024). One hundred and forty-eight cases were matched 1:1 with non-CREC UTI controls by department, gender, and age (±1 year). Univariate and multivariate logistic regression analyses identified independent risk factors of CREC UTIs. R software was used to construct a prediction nomogram, followed by internal validation. Results: CREC urine isolation rate was 1.90% (162/8517). Among 162 CREC patients, 35.80% were male, the mean age was 60.21 ± 17.28 years. Patients' source departments included urology (42, 25.93%), outpatient clinics (23, 14.20%), and ICU (16, 9.88%). 56.2% of patients had underlying urinary tract diseases. CREC strains exhibited >90% resistance to most antibiotics. CREC group had significantly higher UTI reinfection rate than non-CREC group ( Conclusion: Patients with CREC UTIs were predominantly middle-aged and elderly women. Most patients had underlying urinary system diseases. CREC strains exhibited multidrug resistance. Patients had a significantly higher recurrence rate of UTIs. A nomogram based on recurrent UTIs, urinary stone, surgical procedures, urinary catheterization duration ≥7 days, ≥2 antibacterial drugs, and Carbapenems pre-infection displayed high accuracy and consistency in predicting CREC UTIs.
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