Evidence map›Paper›PMID 42381253›Full record

ArticleComprehensive Physiology2026

Heart-Specific Spinal and Vagal Afferents: Transcriptomic Signatures and Optogenetically Modulated Functional Coupling With Cardiomyocytes.

T Akgul Caglar, Y E Kazci, Z B Durdu, S Sahoglu Goktas, S Bay, E Vatandaslar, M U Turhan, G Ozturk, E Cagavi

Abstract read
In one paragraph

Article in Comprehensive Physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

T Akgul CaglarResearch Institute for Health Sciences and Technologies (SABITA), Istanbul Medipol University, Istanbul, Türkiye.
Y E KazciResearch Institute for Health Sciences and Technologies (SABITA), Istanbul Medipol University, Istanbul, Türkiye.ORCID https://orcid.org/0000-0002-4610-9920
Z B DurduResearch Institute for Health Sciences and Technologies (SABITA), Istanbul Medipol University, Istanbul, Türkiye.
S Sahoglu GoktasResearch Institute for Health Sciences and Technologies (SABITA), Istanbul Medipol University, Istanbul, Türkiye.
S BayResearch Institute for Health Sciences and Technologies (SABITA), Istanbul Medipol University, Istanbul, Türkiye.
E VatandaslarResearch Institute for Health Sciences and Technologies (SABITA), Istanbul Medipol University, Istanbul, Türkiye.ORCID https://orcid.org/0000-0002-4681-9703
M U TurhanResearch Institute for Health Sciences and Technologies (SABITA), Istanbul Medipol University, Istanbul, Türkiye.
G OzturkResearch Institute for Health Sciences and Technologies (SABITA), Istanbul Medipol University, Istanbul, Türkiye.
E CagaviResearch Institute for Health Sciences and Technologies (SABITA), Istanbul Medipol University, Istanbul, Türkiye.ORCID https://orcid.org/0000-0002-7199-583X

Funding

Istanbul Medipol University Scientific Research Project Commission (BAP) 2018/19The Scientific and Technological Research Council of Turkey (TUBITAK) 115S381
6 · The paper itself

Abstract

Sensory neurons innervating the heart transmit chemical and mechanical cues to the central nervous system via the dorsal root ganglion (DRG) and nodose ganglion (NG). Despite their importance in cardiac pain and cardiovascular reflexes, the molecular and functional properties of heart-specific sensory (HS) neurons remain elusive. Here, DRG

Indexed as

Ganglia, SpinalHeartMyocytes, CardiacNeurons, AfferentNodose GanglionSensory Receptor CellsTranscriptomeVagus NerveAnimalsMiceOptogeneticsdorsal root and nodose ganglionheart‐specific sensory neuronsneuro‐cardiac interactionsoptogenetic modulation of neuro‐cardiac culturesretrograde labelingtranscriptomic profile

Identifiers

PMID42381253
PMCPMC13320145

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.