Evidence map›Paper›PMID 42381243›Full record

ArticleBritish journal of haematology2026

Outcomes of invasive fungal infections in 358 children undergoing allogeneic haematopoietic stem cell transplantation: A prospective UK study.

Giorgio Ottaviano, Emanuele Lanino, Zohreh Nademi, Beki James, Madeleine Powys, Persis Amrolia, Kanchan Rao, Juliana Silva, Arina Lazareva, Sarah Lawson and 9 more

Abstract read
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In one paragraph

Article in British journal of haematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Giorgio OttavianoDepartment of Blood and Marrow Transplantation, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.ORCID https://orcid.org/0000-0003-3777-0394
Emanuele LaninoPediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Zohreh NademiDepartment of Paediatric Hematopoietic Stem Cell Transplant, Great North Children's Hospital, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
Beki JamesPaediatric Haematology and Oncology, Leeds Children's Hospital, Leeds, UK.
Madeleine PowysDepartment of Blood and Marrow Transplantation, Royal Manchester Children's Hospital, Manchester, UK.
Persis AmroliaDepartment of Blood and Marrow Transplantation, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.ORCID https://orcid.org/0000-0003-0480-3911
Kanchan RaoDepartment of Blood and Marrow Transplantation, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.ORCID https://orcid.org/0000-0001-9449-8476
Juliana SilvaDepartment of Blood and Marrow Transplantation, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Arina LazarevaDepartment of Blood and Marrow Transplantation, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Sarah LawsonDepartment of Haematology, Birmingham Children's Hospital, Birmingham, UK.
Katharine PatrickDepartment of Paediatric Haematology, Sheffield Children NHS Foundation Trust, Sheffield, UK.
Caroline FurnessDepartment of Haematology and Oncology, Royal Marsden Hospital, Sutton, UK.
Olga TatarinovaDepartment of Haematology and Oncology, Royal Marsden Hospital, Sutton, UK.
Bilyana DonchevaPharmacy Department, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Adam IrwinUQ Centre for Clinical Research, The University of Queensland, Brisbane, Queensland, Australia.ORCID https://orcid.org/0000-0001-8974-6789
Anoop CherungonathDepartment of Haematology, Birmingham Children's Hospital, Birmingham, UK.
Joseph Frank StandingInfection, Immunity and Inflammation, Great Ormond Street Institute of Child Health, University College London, London, UK.
Adilia WarrisDepartment of Biosciences, Faculty of Health and Life Sciences, MRC Centre for Medical Mycology, University of Exeter, Exeter, UK.
Robert ChiesaDepartment of Blood and Marrow Transplantation, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.

Funding

Gilead UK and Ireland Corporate Contributions
6 · The paper itself

Abstract

The optimal strategy to prevent and treat invasive fungal infections (IFIs) in children receiving allogeneic haematopoietic stem cell transplantation (HSCT) is not well established. A paediatric bone marrow transplant (BMT) working group set up UK national guidelines for the management of IFI and conducted a prospective study to assess the impact of these on incidence and outcomes. From March 2017 to December 2021, 358 children who received HSCT were prospectively included. Most children (82%) received either itraconazole (41%) or liposomal amphotericin B (41%) prophylaxis with a median duration of 170 days (interquartile range [IQR] 101-279). Cumulative incidence of possible/probable/proven IFI at 1 year was 17.6%, with no significant differences in children receiving itraconazole or liposomal amphotericin B (15.7% vs. 15.9%, 0.997). In multivariate analysis models (Fine-Gray hazard ratio) underlying malignant disease and low azoles therapeutic drug monitoring levels were independently associated with development of IFI. Children with probable/proven IFI had a higher 1-year transplant-related mortality (22% vs. 5.7%, Gray's test, p < 0.001). By adopting standardized anti-fungal prophylaxis, the incidence of proven/probable IFI in a large cohort of transplanted children was 5% and these showed significant decreased survival, warranting tailored prophylactic strategies in high-risk patients.

Indexed as

Hematopoietic Stem Cell TransplantationInvasive Fungal InfectionsAdolescentAmphotericin BAntifungal AgentsChildChild, PreschoolFemaleHumansIncidenceInfantItraconazoleMaleProspective StudiesTransplantation, HomologousTreatment OutcomeAmphotericin BAntifungal AgentsItraconazoleliposomal amphotericin Banti‐fungalhaematopoietic stem cell transplantationinvasive fungal infectionprophylaxis

Identifiers

PMID42381243
PMCPMC13462040

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.