Evidence map›Paper›PMID 42381201›Full record

ReviewPhytochemical analysis : PCA2026

Recent Advances on the Chemical Compositions, Biological Activities, and Applications of Ziziphi Spinosae Semen: From Traditional Treasures to Modern Medical Stars.

Yuchen Tang, Shukui Shang, Xue Runhua, Guixiang Pan, Wenlong Li

Abstract readReview
In one paragraph

Review in Phytochemical analysis : PCA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuchen TangCollege of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Shukui ShangCollege of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Xue RunhuaCollege of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Guixiang PanCollege of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Wenlong LiCollege of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.ORCID https://orcid.org/0000-0001-7961-7975

Funding

first batch of provincial science and technology mission projects in Anhui Province 2023tpt014Major Project of Natural Science Research of Universities in Anhui Province KJ2021ZD0142Special Project for Coordinated Innovation in the Beijing-Tianjin-Hebei Region 25242501D
6 · The paper itself

Abstract

introductionAs sleep disorders and mental stress become increasingly prevalent, public demand for functional foods and health products that improve sleep quality and alleviate insomnia continue to rise. Accordingly, it is necessary to explore natural plants rich in sleep-modulating bioactive substances. Ziziphi spinosae semen (ZSS), the dried mature seed of Ziziphus jujuba Mill., is a well-known medicinal and edible material with sedative and hypnotic effects. It can be processed into various food products and serves as raw material for pharmaceuticals and cosmetics. The chemical constituents of ZSS, including fatty oils, saponins, and flavonoids, contribute to its sedative, anxiolytic, antidepressant, and anti-inflammatory activities. Therefore, ZSS boasts promising application prospects in the medicinal and food industries.

methodsRelevant literature was retrieved from Google Scholar, PubMed, and Web of Science. Data about chemical constituents, pharmacological effects, and product development of ZSS were systematically collected and analyzed.

resultsThis review summarizes the chemical compositions and pharmacological activities of ZSS, and presents the latest progress in its product application.

conclusionsZSS possesses abundant bioactive compounds and exerts prominent pharmacological activities. It holds great value in chronic disease prevention and treatment, and has been developed into various functional products. Further research is required to realize intensive and rational utilization of ZSS resources.

Indexed as

ZiziphusAnimalsAnti-Inflammatory AgentsFlavonoidsHumansHypnotics and SedativesSaponinsSeedsAnti-Inflammatory AgentsFlavonoidsHypnotics and SedativesSaponinsbiological activitychemical compositionmodern applicationZiziphi spinosae semen

Identifiers

PMID42381201
PMCPMC13433791

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.