Evidence map›Paper›PMID 42381184›Full record

ArticleVirulence2026

Piperine reverses colistin resistance in multidrug resistant Gram-negative pathogens by membrane disruption and ROS damage.

Junkai Zhang, Qiange Liu, Haotian Shao, Mengjing Feng, Zibo Li, Yameng Feng, Hua Wu, Dandan He, Yajun Zhai, Gong-Zheng Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virulence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Junkai ZhangDepartment of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, PR China.ORCID 0009-0000-7224-5216
Qiange LiuDepartment of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, PR China.
Haotian ShaoDepartment of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, PR China.
Mengjing FengDepartment of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, PR China.
Zibo LiDepartment of Veterinary Drug, Shangqiu Meilan Biological Engineering Co., LTD, Shangqiu, Henan, PR China.
Yameng FengDepartment of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, PR China.
Hua WuDepartment of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, PR China.ORCID 0000-0002-1301-3076
Dandan HeDepartment of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, PR China.
Yajun ZhaiDepartment of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, PR China.ORCID 0009-0002-2218-4819
Gong-Zheng HuDepartment of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, PR China.ORCID 0000-0002-7042-5771

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The global spread of colistin (COL) resistance, particularly mediated by

Indexed as

AlkaloidsAnti-Bacterial AgentsBenzodioxolesCell MembraneColistinDrug Resistance, Multiple, BacterialGram-Negative BacteriaPiperidinesPolyunsaturated AlkamidesReactive Oxygen SpeciesAnimalsBiofilmsDrug SynergismEscherichia coliEscherichia coli ProteinsMiceAlkaloidsAnti-Bacterial AgentsBenzodioxolesColistinEscherichia coli ProteinsMCR-1 protein, E coliPiperidinespiperinePolyunsaturated AlkamidesReactive Oxygen Speciesantibiotic resistancecolistinMCR-1Piperinesynergistic mechanism

Identifiers

PMID42381184
PMCPMC13336263

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.