ArticleKnee surgery & related research2026
Effect of intravenous hydrocortisone and periarticular triamcinolone acetonide injection on quadriceps strength recovery in patients undergoing total knee arthroplasty: a prospective randomised controlled trial.
Article in Knee surgery & related research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPostoperative pain management is crucial for optimising recovery after total knee arthroplasty. Adequate pain control facilitates early rehabilitation, enhances quadriceps muscle recovery, improves knee function and improves patient satisfaction. Corticosteroids are widely used for postoperative pain management. However, studies comparing the efficacy of periarticular (PA) and intravenous (IV) corticosteroid injection are limited. Therefore, this study aimed to evaluate the effect of PA and IV corticosteroid injections on quadriceps strength (QS) recovery in patients undergoing total knee arthroplasty.
methodsA total of 59 patients were included in this study. Patients were randomly assigned to two groups: the PA triamcinolone group (n = 29) and the IV hydrocortisone group (n = 30). Patients were followed up for 6 months and their QS, Visual Analogue Scale score, Modified Timed Up and Go (MTUGT) score, Western Ontario and McMaster Universities Osteoarthritis Index score, Knee Society Score and inflammatory marker levels were assessed.
resultsOn postoperative day 3, the PA group exhibited a significantly lower reduction in QS (-43.11% ± 23.36% versus -63.7% ± 17.67%, p = 0.02) and significantly lower changes in MTUGT scores than the IV group (153.3% versus 301.3%, p < 0.01). Additionally, the knee flexion angle was significantly greater in the PA group than in the IV group on postoperative day 3 (91° ± 11° versus 82.6° ± 10.9°, p < 0.01) and at week 2 (103.2° ± 12.2° versus 97.4° ± 8.7°, p = 0.04). C-reactive protein levels were significantly lower in the PA group than in the IV group on postoperative day 1 (10.4; IQR: 5.3-17.2 versus 15.4; IQR: 9.4-28.6, p = 0.01), on day 3 (65.5; IQR: 38.3-96 versus 119.1; IQR: 69.6-146.1, p < 0.01) and at week 2 (3.9 versus 8.9, p = 0.01). On postoperative day 3, the PA group had significantly higher glucose levels than the IV group (115; IQR: 106-127 versus 106; IQR: 93-122, p = 0.02). No wound complications were observed in both groups.
conclusionsPA corticosteroid injection improves knee function in terms of muscle recovery, faster ambulation, increased knee flexion and reduced inflammation for up to 2 weeks after surgery compared with IV corticosteroid injection. A transient increase in serum glucose was observed but is unlikely to be clinically significant.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.