Evidence map›Paper›PMID 42381050›Full record

ArticleBMC microbiology2026

Multidrug-resistant bacterial infections in a tertiary hospitals: culture positivity, pathogen spectrum, and antibiotic susceptibility.

Tahsin Salam, Tufael, Md Abu Bakar Siddique, Kaniz Fatima Bari, Mohd Hasan Mujahid, Asim Debnath, Nabil Deb Nath, Md Sefaut Ullah, Vijay Jagdish Upadhye

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Article in BMC microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Tahsin SalamInternal Medicine and critical care medicine, United Medical College Hospital, Dhaka, 1212, Bangladesh.
TufaelDepartment of Biochemistry, Parul University, Vadodara, Gujarat, 391760 , India.
Md Abu Bakar SiddiqueDepartment of Biological Sciences, St John's University, NY, 11439, United States of America.
Kaniz Fatima BariDepartment of Biochemistry, Shaphena Women's Dental College, Dhaka, 1217, Bangladesh.
Mohd Hasan MujahidDepartment of Polymer and Process Engineering, Indian Institute of Technology Roorkee, Uttarakhand, 247667, India. mhasanmujahid@gmail.com.
Asim DebnathBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, 32827, United States of America.
Nabil Deb NathDepartment of Biology, The City University of New York, New York, 10031, United States of America.
Md Sefaut UllahDepartment of Biochemistry and Molecular Biology, Jagannath University, Dhaka, 1100, Bangladesh.
Vijay Jagdish UpadhyeDepartment of Microbiology, Parul Institute of Applied Sciences and Research and Development Cell, Parul University, Vadodara, Gujarat, 391760, India. vijay.upadhye35296@paruluniversity.ac.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAntimicrobial resistance (AMR) is a significant health problem, especially in low- and middle-income countries. This study aimed to investigate the prevalence and trends of antimicrobial resistance (AMR) and multidrug resistance (MDR) in bacterial infections at a tertiary-care hospital in Dhaka, Bangladesh, and the prevalent pathogens and their resistance profiles.

methodsA cross-sectional study was conducted on clinical specimens from patients admitted to tertiary-care hospitals, processed at Ibn Sina Diagnostic and Imaging Center in Dhaka, Bangladesh. A total of 3,996 clinical specimens were sampled by patients, with inclusion and exclusion criteria. The samples were blood, urine and wound swabs. Data regarding culture positivity, pathogen distribution and antimicrobial susceptibility were summarized using descriptive statistics.

resultOut of the 3,996 specimens, 72.5% were positive in terms of significant bacterial growth. The gram-negative bacteria were the dominant ones, with Escherichia coli (25.4%) and Klebsiella spp. (20.4%). The most common pathogens are Pseudomonas aeruginosa (15.8%), Acinetobacter spp. (11.9%), Staphylococcus aureus (10%), and Coagulase-negative Staphylococci (8.1%) were the most common gram-positive. In E. coli, the resistance was significantly high with a 42.5% ciprofloxacin resistance and a 47.0% ceftriaxone resistance. MDR was identified in 53.0% of E. coli isolates, and similar MDR patterns were observed in Klebsiella spp. and Pseudomonas aeruginosa.

conclusionThe study shows that there is high-AMR, especially amongst gram-negative pathogens, at a tertiary-care hospital. There is an urgent need to enhance antibiotic stewardship and infection control to deal with the increasing rate of MDR bacterial infections.

Indexed as

Anti-Bacterial AgentsBacteriaBacterial InfectionsDrug Resistance, Multiple, BacterialGram-Negative BacteriaAdolescentAdultAgedBangladeshChildChild, PreschoolCross-Sectional StudiesFemaleGram-Positive BacteriaHumansInfantAnti-Bacterial AgentsAntibiotic susceptibilityAntimicrobial resistanceBacterial infectionsMultidrug-resistantPathogen spectrum

Identifiers

PMID42381050
PMCPMC13587286

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