ArticleBMC oral health2026
Altered peripheral blood mRNA and salivary biomarkers in dental anxiety: a cross-sectional study.
Article in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
introductionPrevious studies indicate that dental anxiety (DA) is associated with increased salivary cortisol and alpha-amylase, biomarkers of hypothalamic-pituitary-adrenal (HPA) axis and sympathetic-adrenal-medullary (SAM) activation. However, underlying molecular mechanisms remain unclear. This study aimed to explore whether peripheral blood mRNA expression levels of glucocorticoid receptor (GR), GR transcripts containing exons 1B (GR-1B), glutamate ionotropic receptor AMPA type subunit 1 (GRIA1), oxytocin (OT), oxytocin receptor (OTR), and Poly ADP-Ribose Polymerase 1 (PARP1), together with salivary cortisol and alpha-amylase levels, are associated with dental anxiety.
methodsIn this cross-sectional study, a total of 30 DA patients and 28 non-DA patients were included. The mRNA expression levels of GR, GR-1B, GRIA1, OT, OTR, and PARP1 in peripheral blood were determined by real-time quantitative polymerase chain reaction. Salivary cortisol and alpha-amylase concentrations were determined by enzyme-linked immunosorbent assay.
resultsThe expression levels of GR-1B mRNA were significantly higher in the DA group than in the non-DA group, whereas GRIA1 and OT mRNA expression levels were lower in the DA group. Concurrently, salivary cortisol and alpha-amylase levels were significantly higher in the DA group.
conclusionDental anxiety may be associated with altered stress-related molecular expression and salivary biomarkers. These findings provide preliminary evidence of peripheral molecular and salivary changes associated with dental anxiety and may contribute to understanding its biological correlates.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.