Evidence map›Paper›PMID 42380998›Full record

ArticleRespiratory research2026

Isoleucyl-tRNA synthetase 1 mutation impairs pulmonary surfactant homeostasis by disrupting alveolar macrophage function.

Weitao Zhou, Dan Dai, Yao Chen, Xiao Han, Xinran Dong, Yunfei Liao, Tong Chen, Huixian Wang, Chen He, Yilei Lu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Weitao Zhou *Division of Pulmonary Medicine, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Dan Dai *Division of Pulmonary Medicine, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Yao Chen *Division of Pulmonary Medicine, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Xiao HanInstitute of Pediatrics, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Xinran DongInstitute of Pediatrics, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Yunfei LiaoDepartment of Central Laboratory, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Tong ChenInstitute of Pediatric Infection, Immunity and Intensive Care Medicine, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, China.
Huixian WangDivision of Pulmonary Medicine, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Chen HeDivision of Pulmonary Medicine, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Yilei LuDivision of Pulmonary Medicine, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Chenxin ZhengDivision of Pulmonary Medicine, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Yufeng ZhouInstitute of Pediatrics, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China. yfzhou1@fudan.edu.cn.
Liling QianDivision of Pulmonary Medicine, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. llqian@126.com.ORCID https://orcid.org/0009-0001-2113-1339

Funding

Fujian Provincial Department of Science and Technology 2022D012National Natural Science Foundation of China 82171707
6 · The paper itself

Abstract

Biallelic isoleucyl-tRNA synthetase 1 (IARS1) variants are associated with an IARS1-related phenotype characterized by growth retardation, intellectual disability, muscular hypotonia, infantile hepatopathy, and interstitial lung disease. This rare, early-onset disorder is often lethal. Although several variants have been identified in recent years, their pathogenicity and underlying molecular mechanisms remain poorly understood. In this study, we generated Iars1

Indexed as

HomeostasisMacrophages, AlveolarMutationPulmonary Alveolar ProteinosisPulmonary SurfactantsAnimalsMaleMiceMice, Inbred C57BLPulmonary SurfactantsCathepsin ZGene variantsIsoleucyl-tRNA synthetase 1Pulmonary alveolar proteinosis

Identifiers

PMID42380998
PMCPMC13584253

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.