Evidence map›Paper›PMID 42380881›Full record

ReviewJournal of neuroengineering and rehabilitation2026

Biohybrid cochlear implants: neural interfaces, regenerative pathways, and translational benchmarks.

Akihiro J Matsuoka, Andrew N Carpino, Audrey Meador, Beatriz O Nicolau, Gabriela M Fortuño, Huimin Zhu, Tifany T Nguyen, Kiersten R Russ, Hudson Liu, Jae Joon Kim and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of neuroengineering and rehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Akihiro J MatsuokaDepartment of Otolaryngology-Head and Neck Surgery, University of California San Diego, 9444 Medical Center, MC7895, La Jolla, 92037, CA, USA. akmatsuoka@ucsd.edu.ORCID https://orcid.org/0009-0006-6926-4604
Andrew N Carpino *Department of Bioengineering, University of California San Diego, 9500 Gilman Dr, San Diego, 92093, CA, USA.
Audrey Meador *Department of Bioengineering, University of California San Diego, 9500 Gilman Dr, San Diego, 92093, CA, USA.
Beatriz O Nicolau *Department of Bioengineering, University of California San Diego, 9500 Gilman Dr, San Diego, 92093, CA, USA.
Gabriela M Fortuño *Department of Bioengineering, University of California San Diego, 9500 Gilman Dr, San Diego, 92093, CA, USA.
Huimin Zhu *Department of Bioengineering, University of California San Diego, 9500 Gilman Dr, San Diego, 92093, CA, USA.
Tifany T Nguyen *Department of Bioengineering, University of California San Diego, 9500 Gilman Dr, San Diego, 92093, CA, USA.
Kiersten R RussDepartment of Otolaryngology-Head and Neck Surgery, University of California San Diego, 9444 Medical Center, MC7895, La Jolla, 92037, CA, USA.
Hudson LiuDepartment of Otolaryngology-Head and Neck Surgery, University of California San Diego, 9444 Medical Center, MC7895, La Jolla, 92037, CA, USA.
Jae Joon KimDepartment of Otolaryngology-Head and Neck Surgery, University of California San Diego, 9444 Medical Center, MC7895, La Jolla, 92037, CA, USA.
Winston LohDepartment of Otolaryngology-Head and Neck Surgery, University of California San Diego, 9444 Medical Center, MC7895, La Jolla, 92037, CA, USA.
James FriendDepartment of Bioengineering, University of California San Diego, 9500 Gilman Dr, San Diego, 92093, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cochlear implants (CIs) restore hearing by electrically stimulating the auditory nerve, yet the millimeter-scale electrode-neuron separation limits spatial selectivity and temporal fidelity. Rather than relocating the electrode array, we propose a biohybrid strategy that preserves the conventional scala tympani insertion and closes this gap biologically by interposing living neural constructs between the array and the modiolus. This approach leverages the Canaliculi Perforantes of Schuknecht (CPS) to deliver spatially confined biochemical, mechanical, and electrical cues from the scala tympani, biasing spiral ganglion neurites toward contacts while respecting surgical practicality. We review CPS microanatomy and transport, auditory neuron/stem cell-regeneration prospects, hydrogel/assembloid niches, surface and material stacks, and conclude with translational benchmarks, constraints, and a near-mid-long-term roadmap.

Indexed as

Cochlear ImplantsNerve RegenerationAnimalsCochlear ImplantationHumansBDNFBiomaterialCochlear implantHuman induced pluripotent stem cells

Identifiers

PMID42380881
PMCPMC13591839

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.