Evidence map›Paper›PMID 42380764›Full record

ArticleBMC genomics2026

Kaiso overexpression promotes an interferon immune response in murine intestines.

Lindyann R Lessey, Hanad Adan, Shaiya C Robinson, Roopali Chaudhary, Shruthilayaa Sivakumar, Stephanie Ali Fairbairn, Danial Mohammadi, Kyle Kim, Dereck Alleyne, Kathleen E Houlahan and 3 more

Abstract read
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In one paragraph

Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lindyann R LesseyDepartment of Biology, McMaster University, Hamilton, ON, Canada. lesseyl@mcmaster.ca.
Hanad AdanDepartment of Biology, McMaster University, Hamilton, ON, Canada.
Shaiya C RobinsonSchool of Interdisciplinary Science, McMaster University, Hamilton, ON, Canada.
Roopali ChaudharyDepartment of Biology, McMaster University, Hamilton, ON, Canada.
Shruthilayaa SivakumarDepartment of Biology, McMaster University, Hamilton, ON, Canada.
Stephanie Ali FairbairnDepartment of Biology, McMaster University, Hamilton, ON, Canada.
Danial MohammadiDepartment of Biology, McMaster University, Hamilton, ON, Canada.
Kyle KimDepartment of Biology, McMaster University, Hamilton, ON, Canada.
Dereck AlleyneDepartment of Surgery, School of Medicine, Washington University, St. Louis, MO, United States of America.
Kathleen E HoulahanCentre for Discovery in Cancer Research, McMaster University, Hamilton, ON, Canada.
Pierre-André BédardDepartment of Biology, McMaster University, Hamilton, ON, Canada.
Robert W CowanDepartment of Biology, McMaster University, Hamilton, ON, Canada.
Juliet M DanielDepartment of Biology, McMaster University, Hamilton, ON, Canada. danielj@mcmaster.ca.

Funding

Cancer Research Society 840883Natural Sciences and Engineering Research Council RGPIN-2020-06822Natural Sciences and Engineering Research Council of Canada RGPIN-2020-06822
6 · The paper itself

Abstract

The POZ-ZF transcription factor Kaiso plays important roles in vertebrate development and tumorigenesis and binds DNA with dual-specificity at both a consensus DNA sequence and methyl-CpG sites. In murine intestines, Kaiso overexpression induces a chronic inflammatory phenotype that involves NFκB signaling and neutrophil activation. However, a thorough understanding of the molecular mechanisms and signaling pathways involved in the Kaiso-induced inflammatory response warrant further investigation. In this study, global transcriptomes of ileal tissue from 6-week-old Kaiso overexpressing transgenic (Kaiso

Indexed as

Interferon Type IIntestinesTranscription FactorsAnimalsGene Expression ProfilingInterferon Regulatory Factor-7Intestinal MucosaMiceMice, TransgenicPromoter Regions, GeneticSignal TransductionInterferon Regulatory Factor-7Interferon Type ITranscription FactorsImmune responseInterferon responseIntestinal inflammationIRF7KaisoTg miceRNA sequencingZBTB33/Kaiso

Identifiers

PMID42380764

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.