Evidence map›Paper›PMID 42380747›Full record

ArticleBMC genomics2026

Fgf evolution in vertebrates: insights from cyclostomes.

Liyan He, Zheng Dong, Baichuan Tong, Suhan Liu, Fujiang Liu, Zixiang Wu, Guang Li, Qingming Qu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Liyan He *State Key Laboratory of Cellular Stress Biology, Department of Neonatology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiang'an Hospital of Xiamen University, Xiamen University, Xiamen, 361102, Fujian, China.
Zheng Dong *State Key Laboratory of Cellular Stress Biology, Department of Neonatology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiang'an Hospital of Xiamen University, Xiamen University, Xiamen, 361102, Fujian, China.
Baichuan TongState Key Laboratory of Cellular Stress Biology, Department of Neonatology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiang'an Hospital of Xiamen University, Xiamen University, Xiamen, 361102, Fujian, China.
Suhan LiuState Key Laboratory of Cellular Stress Biology, Department of Neonatology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiang'an Hospital of Xiamen University, Xiamen University, Xiamen, 361102, Fujian, China.
Fujiang LiuState Key Laboratory of Cellular Stress Biology, Department of Neonatology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiang'an Hospital of Xiamen University, Xiamen University, Xiamen, 361102, Fujian, China.
Zixiang WuState Key Laboratory of Cellular Stress Biology, Department of Neonatology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiang'an Hospital of Xiamen University, Xiamen University, Xiamen, 361102, Fujian, China.
Guang LiState Key Laboratory of Cellular Stress Biology, Department of Neonatology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiang'an Hospital of Xiamen University, Xiamen University, Xiamen, 361102, Fujian, China. guangli@xmu.edu.cn.
Qingming QuState Key Laboratory of Cellular Stress Biology, Department of Neonatology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiang'an Hospital of Xiamen University, Xiamen University, Xiamen, 361102, Fujian, China. quqingming@xmu.edu.cn.ORCID https://orcid.org/0000-0002-8291-8493

Funding

National Natural Science Foundation of China 32070458National Natural Science Foundation of China 42272013Natural Science Foundation of Fujian Province of China 2022J06004Natural Science Foundation of Xiamen, China 3502Z202473009Xiamen University start-up
6 · The paper itself

Abstract

backgroundFibroblast growth factors (FGFs) are crucial for animal development, growth and physiological regulation. Early vertebrate evolution was shaped by complex whole-genome duplications (WGDs); after a shared first event (1R

resultsOur analysis surprisingly reveals a significantly reduced FGF repertoire in lampreys (17 genes) and hagfishes (12 genes) compared to jawed vertebrates (22-32 genes). This finding suggests extensive FGF gene loss in cyclostomes following their unique genome duplication history. Phylogenetic and synteny analyses confirm that all eight ancestral FGF subfamilies were first established in the common ancestor of vertebrates. Significantly, we report the discovery of a novel FGF gene, Fgf25, within the FGF4/5/6/25 subfamily, uniquely retained in actinopterygians but lost in sarcopterygians. We also propose a new evolutionary model for Fgf3, suggesting its origin via tandem duplication of an unknown Fgf gene after the 1R

conclusionsThis detailed characterization of the cyclostome FGF repertoire provides insights into early vertebrate FGF evolution and a valuable resource for future investigations into cyclostome evolution and development.

Indexed as

Evolution, MolecularFibroblast Growth FactorsLampreysVertebratesAnimalsGene DuplicationGenomeHagfishesMultigene FamilyPhylogenySyntenyFibroblast Growth FactorsCyclostomesFibroblast growth factors (FGFs)Gene family evolutionPhylogenetics and syntenyWhole-genome duplication (WGD)

Identifiers

PMID42380747
PMCPMC13591910

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