Trial reportNature cancer2026
Long-term outcomes of adjuvant metronomic capecitabine in locoregionally advanced nasopharyngeal carcinoma: a randomized, controlled, multicenter, phase 3 study.
Abstract readRandomized Controlled TrialMulticenter StudyClinical Trial, Phase III
In one paragraph
Trial report in Nature cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
44 authors.
Ya-Lan Tao *Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Dong-Hong Wu *Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Qin Zhou *Department of Oncology, Xiangya Hospital, Central South University, Changsha, China.
Kun-Yu Yang *Department of Oncology, Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Feng Jin *Department of Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Xiao-Dong Zhu *Department of Radiation Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Department of Oncology, Affiliated Wuming Hospital of Guangxi Medical University, Nanning, China.
Mei Shi *Department of Radiation Oncology, Xijing Hospital of Fourth Military Medical University, Xi'an, China.
Guo-Qing Hu *Department of Oncology, Cancer Center, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
Yan SunDepartment of Radiation Oncology, Peking University Cancer Hospital, Beijing, China.
Hong-Fen WuDepartment of Radiation Oncology, Jilin Cancer Hospital, Changchun, China.
Hui WuDepartment of Radiation Oncology, Henan Cancer Hospital, Zhengzhou, China.
Qin LinDepartment of Radiation Oncology, Xiamen Cancer Center, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Hui WangDepartment of Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.
Ye TianDepartment of Radiation Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Ning ZhangDepartment of Radiation Oncology, The First People's Hospital of Foshan, Foshan, China.
Xi-Cheng WangDepartment of Radiation Oncology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China.ORCID http://orcid.org/0000-0002-8490-9785
Liang-Fang ShenDepartment of Oncology, Xiangya Hospital, Central South University, Changsha, China.
Zheng-Zheng LiuDepartment of Oncology, Xiangya Hospital, Central South University, Changsha, China.
Jing HuangDepartment of Oncology, Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xiu-Ling LuoDepartment of Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Ling LiDepartment of Radiation Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Department of Oncology, Affiliated Wuming Hospital of Guangxi Medical University, Nanning, China.
Jian ZangDepartment of Radiation Oncology, Xijing Hospital of Fourth Military Medical University, Xi'an, China.
Qi MeiDepartment of Oncology, Cancer Center, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
Bao-Min ZhengDepartment of Radiation Oncology, Peking University Cancer Hospital, Beijing, China.
Dan YueDepartment of Radiation Oncology, Jilin Cancer Hospital, Changchun, China.
Jing XuDepartment of Radiation Oncology, Henan Cancer Hospital, Zhengzhou, China.
San-Gang WuDepartment of Radiation Oncology, Xiamen Cancer Center, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Lei ChenDepartment of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Wen-Fei LiDepartment of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.ORCID http://orcid.org/0000-0001-7605-3609
Guan-Qun ZhouDepartment of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.ORCID http://orcid.org/0000-0002-7989-4224
Rui SunDepartment of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Rui GuoDepartment of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Yuan ZhangDepartment of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Cheng XuDepartment of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Jia-Wei LvDepartment of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.ORCID http://orcid.org/0000-0001-9278-0929
Ying GuoClinical Trials Center, Sun Yat-sen University Cancer Center, Guangzhou, China.
Hui-Xia FengDepartment of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Ling-Long TangDepartment of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.ORCID http://orcid.org/0000-0002-8561-1454
Fang-Yun XieDepartment of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Xu LiuDepartment of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China. liuxu@sysucc.org.cn.ORCID http://orcid.org/0000-0003-4827-5524
Ying SunDepartment of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China. sunying@sysucc.org.cn.ORCID http://orcid.org/0000-0002-5888-2929
Jun MaDepartment of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China. majun2@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-1137-9349
Yan-Ping MaoDepartment of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China. maoyp@sysucc.org.cn.ORCID http://orcid.org/0000-0003-1027-071X
Yu-Pei ChenDepartment of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China. chenyup1@sysucc.org.cn.ORCID http://orcid.org/0000-0002-0010-3494
Funding
National Natural Science Foundation of China (National Science Foundation of China) 81930072National Natural Science Foundation of China (National Science Foundation of China) 82172749National Natural Science Foundation of China (National Science Foundation of China) 82172870National Natural Science Foundation of China (National Science Foundation of China) 82473562Natural Science Foundation of Guangdong Province (Guangdong Natural Science Foundation) 2017A030312003
Abstract
Here we report long-term outcomes of adjuvant metronomic capecitabine in patients with locoregionally advanced nasopharyngeal carcinoma. In this multicenter, open-label, parallel-group, randomized, controlled, phase 3 trial, 406 patients who had completed definitive chemoradiotherapy were randomly assigned (1:1) to receive either adjuvant metronomic capecitabine (650 mg m
Indexed as
Antimetabolites, AntineoplasticCapecitabineNasopharyngeal CarcinomaNasopharyngeal NeoplasmsAdministration, MetronomicAdultAgedCarcinomaChemotherapy, AdjuvantDisease-Free SurvivalFemaleHumansMaleMiddle AgedTreatment OutcomeAntimetabolites, AntineoplasticCapecitabine
Identifiers
PMID
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.