ArticleScientific reports2026
Scutellaria baicalensis root-derived silver nanoparticles for enhanced Baicalin's biological activities to inhibit breast cancer cells.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Breast cancer (BC) remains a major global health challenge, particularly aggressive subtypes such as triple-negative breast cancer (TNBC), which often exhibit poor therapeutic response and systemic toxicity. Baicalin (BA) possesses promising anticancer activity; however, its clinical application is limited by poor solubility, low bioavailability, and limited cellular uptake. The study aimed to synthesise baicalin-silver nanoparticles (BA-AgNPs) and to evaluate whether the nanoformulation could enhance the antioxidant, biocompatibility, and anticancer potential of BA against BC cells. BA-AgNPs were synthesised using a green reduction approach and characterised by UV-vis spectroscopy, FTIR, dynamic light scattering, zeta potential, SEM, and HR-TEM analysis. Antioxidant activity was evaluated using DPPH, FRAP, ABTS, H
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