ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026
Psychological distress in patients with hematological malignancies during the 2023-2025 war in Israel: a national survey and comparison with the COVID-19 pandemic.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPatients with hematological malignancies are vulnerable to psychological distress in times of crisis. We evaluated emotional burden, including demographic and clinical factors associated with war-related fears and depression severity, as well as coping strategies, and care continuity during the 2023-2025 war in Israel and compared findings to a prior COVID-19 survey.
methodsA national cross-sectional survey was conducted in September 2025 among Hebrew-speaking patients with hematological malignancies. Data included sociodemographic and clinical items, disease management, fears (Likert scales), the Patient Health Questionnaire-9 (PHQ-9), and three open-ended questions analyzed thematically. Results were compared with a similar 2021 COVID-19 survey.
resultsOf 836 patients approached, 188 responded (22%). War affected many patients: 45% had a relative recruited to the army, and 2% reported evacuation or a family member injured/killed. Treatment disruptions were limited (8% delays, 7% alternative therapy, one deferred CAR-T). Depression was frequent (mean PHQ-9 was 10.4 ± 5.6), with 49% in moderate-to-severe ranges, significantly higher than during COVID-19 (9.2 ± 5.9, p = 0.022). Female sex and the wartime period independently predicted depression severity. Mean fear regarding clinic safety was 1.9 ± 1.4 on a 7-point Likert scale and was higher in women, older and lymphoma patients. Thematic analysis revealed fear/anger about war and government (38%) as the most common difficulty, while family support (23%) was the main coping resource.
conclusionsCompared to the COVID-19 pandemic, the 2023-2025 war was associated with greater depression severity despite fewer care disruptions. Hematology services should incorporate systematic screening and psychosocial support to safeguard patient well-being during crises.
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