Evidence map›Paper›PMID 42380228›Full record

ArticleScientific reports2026

Influence of high-fat diet and sex on connective tissue in carpal tunnel syndrome.

Tomoyuki Kuroiwa, Hayman Lui, Koichi Nakagawa, Naoya Iida, Claire Desrochers, Rou Wan, Ken Nishimura, Elameen Adam, Dirk Larson, Peter Amadio and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Tomoyuki KuroiwaDepartment of Orthopedic Surgery, Mayo Clinic, 200 First St. SW, Rochester, MN, USA.
Hayman LuiDepartment of Orthopedic Surgery, Mayo Clinic, 200 First St. SW, Rochester, MN, USA.
Koichi NakagawaDepartment of Orthopedic Surgery, Mayo Clinic, 200 First St. SW, Rochester, MN, USA.
Naoya IidaDepartment of Orthopedic Surgery, Mayo Clinic, 200 First St. SW, Rochester, MN, USA.
Claire DesrochersDepartment of Orthopedic Surgery, Mayo Clinic, 200 First St. SW, Rochester, MN, USA.
Rou WanDepartment of Orthopedic Surgery, Mayo Clinic, 200 First St. SW, Rochester, MN, USA.
Ken NishimuraDepartment of Orthopedic Surgery, Mayo Clinic, 200 First St. SW, Rochester, MN, USA.
Elameen AdamDepartment of Orthopedic Surgery, Mayo Clinic, 200 First St. SW, Rochester, MN, USA.
Dirk LarsonDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Peter AmadioDepartment of Orthopedic Surgery, Mayo Clinic, 200 First St. SW, Rochester, MN, USA. pamadio@mayo.edu.
Anne GingeryDepartment of Orthopedic Surgery, Mayo Clinic, 200 First St. SW, Rochester, MN, USA. gingery.anne@mayo.edu.

Funding

The Role of Cellular Senescence in Carpal Tunnel Syndrome.R01AR076347 · NIAMS · MAYO CLINIC ROCHESTER · PI Anne Gingery · 2020 to 2026
$3.3M
NIH HHS R01AR076347
6 · The paper itself

Abstract

Carpal tunnel syndrome (CTS) is a common musculoskeletal disorder, characterized by thickening and fibrosis of the subsynovial connective tissue (SSCT). Risk factors for CTS includes sex, metabolic dysfunction and age. Interestingly although the overall prevalence of CTS is higher in women than in men, men exhibit a greater incidence under conditions of metabolic dysfunction. This suggests a focus on metabolic and sex specific therapeutic strategies for the treatment of patients with CTS. In this study we hypothesized that a high-fat diet (HFD), a common driver of metabolic dysfunction, would promote SSCT thickening in CTS and that this response would be sex dependent. To test this, we examined the effects of HFD and sex on SSCT thickening and markers of fibrosis using our established CTS rabbit model of SSCT thickening. Forty-eight mature adult rabbits (24 male and 24 female) were assigned to four groups including HFD or standard diet (STD), each with and without CTS induction. SSCT was collected for histological and gene expression analysis. Here we found that HFD promoted SSCT thickening and upregulated profibrotic genes, including TGF-β, with additional fibrotic genes exhibiting sex-specific differential expression.

Indexed as

Carpal tunnel syndromeHigh-fat dietRabbitSexSubsynovial connective tissue

Identifiers

PMID42380228
PMCPMC13623633

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.