ArticleTranslational psychiatry2026
Latent subdimensions of anxiety and depression differentially influence exertion of effort in pursuit of reward versus avoidance of threat.
Article in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Anxiety and depression are highly comorbid. Across species, depression-related phenotypes have been linked to reduced willingness to expend effort to pursue rewards. Effortful threat avoidance has been less extensively studied. Here, we used a dimensional model of psychopathology to investigate whether distinct sub-dimensions of depressed and anxious affect differentially impact effortful reward pursuit versus threat avoidance in humans. Hierarchical Bayesian modeling revealed that component decision-making mechanisms underlying effortful reward pursuit were differentially impacted by latent dimensions capturing the depressive symptoms of apathy versus anhedonia. Meanwhile, only the latent dimension tapping worry-related symptoms significantly impacted effortful threat avoidance, increasing willingness to exert effort to avoid threat and reducing sensitivity to threat magnitude.
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