Evidence map›Paper›PMID 42380122›Full record

ArticleCell death & disease2026

Genetically modulating the RNA-binding protein Regnase-1 reveals its critical role in regulatory T cell homeostasis and function in vivo.

Xiaojun Su, Xiang Xiao, Ge Deng, Si Sun, Mou Wen, Ashton A Connor, Zhuyun Mao, Rafik M Ghobrial, Wenhao Chen, Xian C Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaojun SuImmunobiology and Transplant Science Center, Department of Surgery, Houston Methodist Hospital, Texas Medical Center, Houston, TX, USA.
Xiang XiaoImmunobiology and Transplant Science Center, Department of Surgery, Houston Methodist Hospital, Texas Medical Center, Houston, TX, USA.
Ge DengImmunobiology and Transplant Science Center, Department of Surgery, Houston Methodist Hospital, Texas Medical Center, Houston, TX, USA.
Si SunImmunobiology and Transplant Science Center, Department of Surgery, Houston Methodist Hospital, Texas Medical Center, Houston, TX, USA.
Mou WenImmunobiology and Transplant Science Center, Department of Surgery, Houston Methodist Hospital, Texas Medical Center, Houston, TX, USA.
Ashton A ConnorImmunobiology and Transplant Science Center, Department of Surgery, Houston Methodist Hospital, Texas Medical Center, Houston, TX, USA.
Zhuyun MaoImmunobiology and Transplant Science Center, Department of Surgery, Houston Methodist Hospital, Texas Medical Center, Houston, TX, USA.
Rafik M GhobrialImmunobiology and Transplant Science Center, Department of Surgery, Houston Methodist Hospital, Texas Medical Center, Houston, TX, USA.
Wenhao ChenImmunobiology and Transplant Science Center, Department of Surgery, Houston Methodist Hospital, Texas Medical Center, Houston, TX, USA.
Xian C LiImmunobiology and Transplant Science Center, Department of Surgery, Houston Methodist Hospital, Texas Medical Center, Houston, TX, USA. xcli@houstonmethodist.org.ORCID http://orcid.org/0000-0002-5981-2762

Funding

Control of Treg exhaustion by OX40R01AI106200 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI LI, XIAN CHANG · 2014 to 2025
$4.2M
IRF4-dependent T-cell effector programs in governing transplant outcomesR01AI132492 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI CHEN, WENHAO · 2018 to 2022
$2.0M
Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) R01AI106200Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) R01AI132492NIAID NIH HHS R01 AI106200NIAID NIH HHS R01 AI132492
6 · The paper itself

Abstract

Regnase-1 is a CCCH-type RNA-binding protein that constantly degrades mRNA species via its ribonuclease domain to maintain immune quiescence. But how and by what mechanisms Regnase-1 regulates Foxp3

Indexed as

HomeostasisRibonucleasesT-Lymphocytes, RegulatoryAnimalsAutoimmune DiseasesForkhead Transcription FactorsMaleMiceForkhead Transcription FactorsFoxp3 protein, mouseRibonucleasesZc3h12a protein, mouse

Identifiers

PMID42380122
PMCPMC13586167

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.