ArticleNature communications2026
Modular synthesis of trisubstituted olefins and 1,3-dienes from renewable alcohols via ligand-enabled nickel catalysis.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Olefins are fundamental functional groups and of substantial commercial importance across a broad range of value-added chemicals. Their production from biomass-derived alcohols remains a longstanding goal, while the selective synthesis of trisubstituted olefins presents a formidable challenge that demands precise catalytic control to suppress undesired product formation. Herein, we demonstrate sequential cross-coupling/isomerization and cross-coupling/dehydrogenation of two different alcohols leading to stereoselective synthesis of trisubstituted olefins (27 examples; E/Z up to 98:2) and 1,3-dienes (23 examples; E/Z > 20:1) using a commercially available nickel catalyst enabled by ligand control. Late-stage functionalization using DL-galactose, α-tocopherol and post-product modification to a tamoxifen analogue and polyaromatic hydrocarbon highlight the significance of our developed method. Preliminary mechanistic studies indicate that alcohol dehydrogenation to the corresponding aldehyde is the rate-determining step (P
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.