Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
18 authors.
Taisei Wakigawa *Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan.ORCID 0000-0003-4369-3364
Yusuke Kimura *Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan.
Mari MitoRNA Systems Biochemistry Laboratory, Pioneering Research Institute, RIKEN, Wako, Saitama, Japan.ORCID 0000-0003-2564-6273
Toshiya TsubakiSensory & Motor System Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan.ORCID 0000-0003-4576-1877
Muhoon LeeDepartment of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan.
Koki NakamuraDepartment of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.ORCID 0000-0003-4885-4526
Abdul Haseeb KhanInstitute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Shenzhen, China.ORCID 0000-0003-4845-7774
Hironori SaitoDepartment of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan.
Tohru YamamoriJapan Space Forum, Chiyoda-ku, Japan.
Tomokazu YamazakiSpace Environment Utilization Center, Human Spaceflight Technology Directorate, Japan Aerospace Exploration Agency, Tsukuba, Japan.
Akira HigashibataSpace Environment Utilization Center, Human Spaceflight Technology Directorate, Japan Aerospace Exploration Agency, Tsukuba, Japan.ORCID 0000-0002-6672-543X
Tatsuhisa TsuboiInstitute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Shenzhen, China.ORCID 0000-0003-3249-030X
Yusuke HirabayashiDepartment of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.ORCID 0000-0003-3950-6781
Nono Takeuchi-TomitaDepartment of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan.
Taku SaitoSensory & Motor System Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan.
Atsushi HigashitaniGraduate School of Life Sciences, Tohoku University, Sendai, Japan.ORCID 0000-0001-6920-0594
Yuichi ShichinoRNA Systems Biochemistry Laboratory, Pioneering Research Institute, RIKEN, Wako, Saitama, Japan.ORCID 0000-0002-0093-1185
Shintaro IwasakiDepartment of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan. shintaro.iwasaki@riken.jp.ORCID 0000-0001-7724-3754
Funding
National Metabolomics Data Repository - nextgen Metabolomics WorkbenchU2CDK119886 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUBRAMANIAM, SHANKAR · 2018 to 2021
$12.7M
Biomedical Data Commons Workbench (BDCW)OT2OD030544 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUBRAMANIAM, SHANKAR · 2020 to 2024
$3.2M
Pacific Biosciences PacBio RS Single Molecule Real Time SequencerS10OD018174 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI ROKHSAR, DANIEL SOLEYMAN · 2014 to 2014
$600k
Japan Agency for Medical Research and Development (AMED) JP19dm0207082Japan Agency for Medical Research and Development (AMED) JP21wm0525015Japan Agency for Medical Research and Development (AMED) JP23gm6910005MEXT | Japan Science and Technology Agency (JST) JPMJCR25T2MEXT | Japan Society for the Promotion of Science (JSPS) JP19K22406MEXT | Japan Society for the Promotion of Science (JSPS) JP22J23099MEXT | Japan Society for the Promotion of Science (JSPS) JP22KJ1154MEXT | Japan Society for the Promotion of Science (JSPS) JP23H00095MEXT | Japan Society for the Promotion of Science (JSPS) JP23H02415MEXT | RIKEN Pioneering ProjectMEXT | RIKEN TRIP-AGISMinistry of Education, Culture, Sports, Science and Technology (MEXT) JP20H05784Ministry of Education, Culture, Sports, Science and Technology (MEXT) JP21H05734Ministry of Education, Culture, Sports, Science and Technology (MEXT) JP22H05532Ministry of Education, Culture, Sports, Science and Technology (MEXT) JP23H04268Ministry of Education, Culture, Sports, Science and Technology (MEXT) JP24H02307NIDDK NIH HHS U2C DK119886NIH HHS OT2 OD030544NIH HHS S10 OD018174
6 · The paper itself
Abstract
Life on Earth has evolved in a form suitable for the gravitational force. Although the pivotal role of gravity in gene expression has been suggested, the molecular details remain unclear. Here, we show that mitochondria utilize gravity to activate protein synthesis within the organelle. Genome-wide ribosome profiling reveals reduced mitochondrial translation in mammalian cells and Caenorhabditis elegans under microgravity. We found that attenuation of cell adhesion through laminin-integrin interactions caused the phenotype. Mitochondrial translation is activated by a signal relayed by FAK, RAC1, PAK1, BAD, and Bcl-2 family proteins in the cytosol, and the mitochondrial fatty acid synthesis (mtFAS) pathway in the matrix. Consumption of mitochondrial malonyl-CoA by mtFAS reduces the malonylation of the translational machinery and accelerates the rates of translational initiation and elongation. Physiologically, this system operates in mechano-response of skeletal muscles. Our work provides mechanistic insights into how cells convert gravitational and mechanical forces into translation in mitochondria.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Gravitational and mechanical forces shape mitochondrial translation. · full record | OpenQuestion