Evidence map›Paper›PMID 42379823›Full record

Observational studyMicrobiology spectrum2026

Impact of early vs delayed initiation of dual antimicrobial salvage therapy on clinical outcomes in MRSA bacteremia.

Victoria Sanderford, Nikko Rowe A Tabliago, Sarah Alnami, Susan Spencer, Rachel Colven, Gustavo Rey Alvira-Arill, Zachary Gruss, Laura Ehrenberger, Aaron Hamby, Abby Kosharek and 4 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Victoria SanderfordDepartment of Medicine, Division of Internal Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID 0000-0003-3795-9429
Nikko Rowe A TabliagoDepartment of Medicine, Division of Infectious Diseases, Medical University of South Carolina Health, Charleston, South Carolina, USA.
Sarah AlnamiDepartment of Pharmacy Services, Medical University of South Carolina Health, Charleston, South Carolina, USA.
Susan SpencerDepartment of Medicine, Division of Internal Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
Rachel ColvenDepartment of Pharmacy Services, Medical University of South Carolina Health, Charleston, South Carolina, USA.
Gustavo Rey Alvira-ArillDepartment of Pharmacy Services, Medical University of South Carolina Health, Charleston, South Carolina, USA.
Zachary GrussDepartment of Pharmacy Services, Medical University of South Carolina Health, Charleston, South Carolina, USA.
Laura EhrenbergerDepartment of Pharmacy Services, Medical University of South Carolina Health, Charleston, South Carolina, USA.
Aaron HambyDepartment of Pharmacy Services, Medical University of South Carolina Health, Charleston, South Carolina, USA.
Abby KosharekDepartment of Pharmacy Services, Medical University of South Carolina Health, Charleston, South Carolina, USA.
Stephen ThackerDepartment of Pediatrics, Division of Infectious Diseases, Medical University of South Carolina Health, Charleston, South Carolina, USA.
Krutika Mediwala HornbackDepartment of Pharmacy Services, Medical University of South Carolina Health, Charleston, South Carolina, USA.
Taylor MorrisetteDepartment of Pharmacy Services, Medical University of South Carolina Health, Charleston, South Carolina, USA.
Richard LuekingDepartment of Medicine, Division of Infectious Diseases, Medical University of South Carolina Health, Charleston, South Carolina, USA.ORCID 0000-0003-2029-0415

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our retrospective observational cohort study investigated the effect of the timing of escalation to dual salvage therapy utilizing ceftaroline with vancomycin or daptomycin for the treatment of persistent methicillin-resistant

Indexed as

Anti-Bacterial AgentsBacteremiaMethicillin-Resistant Staphylococcus aureusSalvage TherapyStaphylococcal InfectionsAdultAgedAged, 80 and overCeftarolineCephalosporinsDaptomycinDrug Therapy, CombinationFemaleHumansMaleMiddle AgedAnti-Bacterial AgentsCeftarolineCephalosporinsDaptomycinThird Generation CephalosporinsVancomycinbacteremiaceftarolineMRSAsalvage therapy

Identifiers

PMID42379823
PMCPMC13435828

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.