Evidence map›Paper›PMID 42379799›Full record

ArticleIn vivo (Athens, Greece)

Albumin to Globulin Ratio Is an Independent Prognostic and Predictive Factor for Recurrence of Esophageal Cancer After Esophagectomy.

Mamoru Uchiyama, Toru Aoyama, Yukio Maezawa, Itaru Hashimoto, Ayako Tamagawa, Sosuke Yamamto, Ryuki Esashi, Kazuki Otani, Tetsushi Ishiguro, Miki Kayashima and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Mamoru Uchiyama *Department of Surgery, Yokohama City University, Yokohama, Japan.
Toru Aoyama *Department of Surgery, Yokohama City University, Yokohama, Japan; t-aoyama@lilac.plala.or.jp.
Yukio MaezawaDepartment of Surgery, Yokohama City University, Yokohama, Japan.
Itaru HashimotoDepartment of Surgery, Yokohama City University, Yokohama, Japan.
Ayako TamagawaDepartment of Surgery, Yokohama City University, Yokohama, Japan.
Sosuke YamamtoDepartment of Surgery, Yokohama City University, Yokohama, Japan.
Ryuki EsashiDepartment of Surgery, Yokohama City University, Yokohama, Japan.
Kazuki OtaniDepartment of Surgery, Yokohama City University, Yokohama, Japan.
Tetsushi IshiguroDepartment of Surgery, Yokohama City University, Yokohama, Japan.
Miki KayashimaDepartment of Gastrointestinal Surgery, Yokohama City University, Yokohama, Japan.
Maki TakagiDepartment of Surgery, Yokohama City University, Yokohama, Japan.
Kohei SekiguchiDepartment of Surgery, Yokohama City University, Yokohama, Japan.
Kiyoko ShimadaDepartment of Surgery, Yokohama City University, Yokohama, Japan.
Naoko OkudaDepartment of Surgery, Yokohama City University, Yokohama, Japan.
Momoko FukudaDepartment of Surgery, Yokohama City University, Yokohama, Japan.
Masaki TakahashiDepartment of Surgery, Yokohama City University, Yokohama, Japan.
Mihwa JuDepartment of Surgery, Yokohama City University, Yokohama, Japan.
Natsumi KamiyaDepartment of Surgery, Yokohama City University, Yokohama, Japan.
Keisuke KazamaDepartment of Surgery, Yokohama City University, Yokohama, Japan.
Norio YukawaDepartment of Surgery, Yokohama City University, Yokohama, Japan.
Takaki YoshikawaDepartment of Gastrointestinal Surgery, Yokohama City University, Yokohama, Japan.
Aya SaitoDepartment of Surgery, Yokohama City University, Yokohama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimThe albumin-to-globulin ratio (AGR) is a promising biomarker reflecting both the nutritional and inflammatory status in patients with gastrointestinal malignancies. However, the clinical significance of AGR in patients with recurrent esophageal cancer (EC) remains unclear. The aim of the present study was to evaluate the prognostic and predictive impact of AGR in patients with recurrent EC after esophagectomy. PATIENTS AND

methodsWe retrospectively reviewed data for 91 patients with recurrent EC who received any treatment, including best supportive care, after recurrence at Yokohama City University between 2005 and 2022. The cut-off value of AGR was set at 1.4 based on previous studies and survival outcomes. Overall survival (OS) and treatment responses were compared between the AGR-low (<1.4) and AGR-high (≥1.4) groups.

resultsFifty-three patients were categorized into the AGR-low group and 38 into the AGR-high group. The 1-, 3-, and 5-year OS rates were 28.6%, 12.8% and 12.8%, and 80.3%, 42.0% and 36.7%, respectively. In multivariate analysis, age ≥75 years [hazard ratio (HR)=1.808, 95% confidence interval (CI)=1.028-3.179,

conclusionAGR was an independent prognostic and predictive biomarker in patients with recurrent EC. AGR may serve as a simple and clinically useful biomarker for predicting prognosis and guiding treatment strategies in patients with recurrent EC.

Indexed as

Biomarkers, TumorEsophageal NeoplasmsEsophagectomyGlobulinsNeoplasm Recurrence, LocalSerum AlbuminAgedAged, 80 and overFemaleHumansMaleMiddle AgedNeoplasm StagingPrognosisRetrospective StudiesBiomarkers, TumorGlobulinsSerum AlbuminAGResophageal cancerrecurrencesurvival

Identifiers

PMID42379799
PMCPMC13322054

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.