ArticleIn vivo (Athens, Greece)
Giant Cell Tumor of the Cervical Axis Treated With Anterior-Posterior Surgery and Denosumab: A Ten-year Follow-up Case Report.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimGiant cell tumor of the bone (GCTB) is a benign but locally aggressive neoplasm that rarely involves the cervical spine, accounting for approximately 1-4% of all primary bone tumors. The cervical axis (C2) is an exceptionally rare site, presenting unique surgical challenges due to its complex anatomy and proximity to vital neurovascular structures. Denosumab, a monoclonal antibody targeting RANKL, has emerged as an important adjuvant therapy for unresectable or surgically challenging GCTB. Long-term outcomes of combined surgical resection and denosumab therapy in cervical spine GCTB remain poorly documented. CASE REPORT: We report the case of a 16-year-old Japanese male with a history of malignant lymphoma who presented with neck pain and a lytic lesion of the C2 vertebral body. Imaging revealed a 3.5×2.8×2.5 cm expansile lesion with extraosseous extension and encasement of the right vertebral artery. Biopsy confirmed GCTB. The patient received preoperative denosumab (120 mg on days 1, 8, and 15 of month 1, then monthly for 7 additional months) followed by right vertebral artery embolization. A two-stage anterior-posterior surgical resection was performed
conclusionThis case demonstrates that combined anterior-posterior surgical resection with perioperative denosumab therapy can achieve excellent long-term tumor control and functional outcomes in C2 GCTB. Extended preoperative denosumab facilitated tumor ossification and surgical resection, while postoperative denosumab may reduce recurrence risk. Long-term surveillance remains essential given the variable recurrence patterns in spinal GCTB.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.