ArticleIn vivo (Athens, Greece)
Utility of a Simplified Irradiator for Photosensitivity Testing in Head and Neck Photoimmunotherapy.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
aimHead and neck photoimmunotherapy (HN-PIT) using cetuximab sarotalocan sodium requires post-treatment assessment for photosensitivity, but tests using direct sunlight are affected by weather and lack standardization. This study evaluated a simplified artificial irradiator for more consistent light irradiation testing. PATIENTS AND
methodsThis single-center retrospective study analyzed 16 HN-PIT treatments in 8 patients with unresectable locally advanced or recurrent head and neck cancer. On days 6-7 post-treatment, patients underwent both direct sunlight exposure and a simple irradiation test using a FLASH-PAK projector equipped with an R-60 filter to evaluate reactions around the clinically relevant 690 nm wavelength. Erythema and edema were assessed on the day of the test and 1 month later.
resultsNo photosensitivity reactions occurred with either method, nor were delayed reactions observed.
conclusionThe simplified irradiator allows standardized, weather-independent photosensitivity testing after HN-PIT, although further studies are needed to confirm sensitivity and long-term reliability.
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