Evidence map›Paper›PMID 42379781›Full record

ReviewIn vivo (Athens, Greece)

Esophageal Large-cell Neuroendocrine Carcinoma With Pagetoid Spread: A Case Report and Literature Review.

Shinsuke Maeda, Tomoko Yamamoto, Yuka Kaizu, Rinka Tamazaki, Shunichi Ito, Kei Hosoda, Shigeki Yamaguchi

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shinsuke MaedaDepartment of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan; maeda.shinsuke@twmu.ac.jp.
Tomoko YamamotoDepartment of Surgical Pathology, Tokyo Women's Medical University, Tokyo, Japan.
Yuka KaizuDepartment of Radiation Oncology, Tokyo Women's Medical University, Tokyo, Japan.
Rinka TamazakiDepartment of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan.
Shunichi ItoDepartment of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan.
Kei HosodaDepartment of Surgery, Shonan-Kamakura General Hospital, Kamakura, Japan.
Shigeki YamaguchiDepartment of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimEsophageal neuroendocrine carcinoma (NEC) is known for its aggressive behavior and poor prognosis. However, the characteristics of this disease remain unclear owing to its rarity. CASE REPORT: A 59-year-old male with an esophageal submucosal tumor-like lesion was referred to our department. Esophagogastroduodenoscopy revealed a protruding lesion in the lower esophagus and a wide range of patchy staining in the middle to lower esophagus after iodine spraying. Biopsies yielded a diagnosis of neuroendocrine carcinoma with suspicion of peripheral extension. Robot-assisted subtotal esophagectomy was performed, and histopathological examination confirmed a diagnosis of large-cell neuroendocrine carcinoma (LCNEC) accompanied by pagetoid spread of 13 cm in length. No recurrence has been observed during 24 months of follow-up. To the best of our knowledge, this is the first report of esophageal NEC with pagetoid spread. We conducted a literature review of NEC with pagetoid spread in various organs and analyzed 16 cases, including the present case.

conclusionPagetoid spread is a distinctive characteristic of NECs, especially LCNEC, arising in various organs, including the esophagus. Attention to this characteristic is warranted because it results in undetected cancer spread, which may lead to complications of incomplete therapies or tumor relapses.

Indexed as

Carcinoma, Large CellCarcinoma, NeuroendocrineEsophageal NeoplasmsBiopsyHumansMaleMiddle AgedEsophaguslarge-cellneuroendocrine carcinomapagetoid spread

Identifiers

PMID42379781
PMCPMC13321956

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.