ArticleIn vivo (Athens, Greece)
Antioxidant and Neuroprotective Effects of 20% Marigold Extract Oil (Lutein/Zeaxanthin Complex) in LED-induced Retinal Injury and A2E-mediated ARPE-19 Models.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
aimLutein and zeaxanthin (L/Z) are major components of macular pigment with established antioxidant and blue-light filtering properties. This study investigated the protective efficacy of a 20% marigold extract oil (L/Z complex) using both an A2E-mediated ARPE-19 cell MATERIALS AND
methods
resultsIn ARPE-19 cells, A2E-mediated blue light exposure reduced viability to 28.15±3.67% and markedly increased inflammatory cytokines. L/Z complex significantly reduced NF-κB, interleukin-1 beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) expression while enhancing HO-1 and antioxidant enzyme levels. In the rat model, L/Z complex preserved outer nuclear layer (ONL) thickness, reduced pro-inflammatory cytokines, enhanced total antioxidant capacity (TAC) and glutathione peroxidase (GSH-Px) activities, and attenuated NF-κB expression.
conclusionThe L/Z complex confers retinal protection through coordinated antioxidant and anti-inflammatory mechanisms in both cellular and animal models of retinal injury, supporting its translational potential as a nutritional intervention for retinal degeneration.
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