SynthesisIn vivo (Athens, Greece)
Impact of Climate Change on Legionnaire's Disease: A Systematic Review.
Synthesis in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimLegionnaires' disease is a severe atypical pneumonia caused by MATERIALS AND
methodsThis systematic review followed PRISMA 2020 guidelines and was registered in PROSPERO. Observational epidemiological and environmentally informative studies evaluating associations between meteorological or hydrological variables and Legionnaires' disease outcomes were included. Due to heterogeneity in study design, exposures, outcomes, and analytical methods, a structured narrative synthesis was performed.
resultsTwenty-three studies were included. The most consistent short-term predictors of increased Legionnaires' disease incidence were rainfall, elevated relative or absolute humidity, vapor pressure, and conditions favoring aerosol persistence, usually occurring 6-14 days before symptom onset. Antecedent warm periods several weeks earlier were also associated with increased risk, supporting conditioning and amplification within engineered water systems. Additional evidence implicated hydrological factors, including low river or stream flow and flood-related disturbance, acting over longer lag periods. Environmental sampling and post-disaster studies further supported the mobilization of hidden environmental reservoirs during extreme events.
conclusionLegionnaires' disease is a climate-sensitive infection influenced by interacting short-term meteorological triggers and longer-term climatic and hydrological conditioning of water systems. Climate-aware surveillance combined with proactive water management may help reduce future disease burden under ongoing climate change.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.