Evidence map›Paper›PMID 42379737›Full record

ArticleIn vivo (Athens, Greece)

Longitudinal

Chin Liu, Ying-Chen Chen, Jeng-Wei Lu, Yi-Jung Ho, Shan-Wen Lui, Ting-Yu Hsieh, Wun-Long Jheng, Kuang-Yih Wang, Feng-Cheng Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chin Liu *Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan, R.O.C.
Ying-Chen Chen *Rheumatology/Immunology and Allergy, Department of Internal Medicine, Department of Pediatrics, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan, R.O.C.
Jeng-Wei LuDepartment of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, Taiwan, R.O.C.
Yi-Jung HoSchool of Pharmacy, National Defense Medical University, Taipei, Taiwan, R.O.C.
Shan-Wen LuiDepartment of Internal Medicine, Linkou Chang-Gung Memorial Hospital, Taoyuan, Taiwan, R.O.C.
Ting-Yu HsiehDepartment of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
Wun-Long JhengCancer Center, Hualien Tzu-Chi Hospital, Hualien, Taiwan, R.O.C.
Kuang-Yih WangDepartment of Engineering Medicine, Shizuoka Center for Molecular Intelligence, Hamamatsu, Japan.
Feng-Cheng LiuRheumatology/Immunology and Allergy, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan, R.O.C. lfc10399@mail.ndmutsgh.edu.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimRegulatory T cells (Tregs) are pivotal for maintaining immune tolerance, yet their dynamic changes during the transition from active disease to remission in systemic lupus erythematosus (SLE) remain unclear. We assessed whether specific Treg subpopulations can serve as biomarkers of clinical recovery. PATIENTS AND

methodsWe conducted longitudinal immunophenotyping in eight patients with SLE across healthy, active, and stable disease states tracking CD3

resultsIn contrast to static deficiency models, our longitudinal analysis revealed a distinct dynamic pattern: FoxP3

conclusionThe transient expansion and subsequent normalization of Treg subsets distinguish active inflammation from stable remission, serving as a potential immunophenotypic signature of successful immune resetting in SLE.

Indexed as

ImmunophenotypingLupus Erythematosus, SystemicT-Lymphocytes, RegulatoryAdultBiomarkersFemaleForkhead Transcription FactorsHumansLongitudinal StudiesMaleMiddle AgedT-Lymphocyte SubsetsBiomarkersForkhead Transcription Factorsimmune modulationimmunophenotypingRegulatory T cellssystemic lupus erythematosusTregs

Identifiers

PMID42379737
PMCPMC13321966

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.