Evidence map›Paper›PMID 42379661›Full record

ArticleOpen heart2026

Beyond the slope: prognostic utility of the VE/VCO

Piergiuseppe Agostoni, Robin Willixhofer, Arianna Galotta, Filippo Maria Rubbo, Stefano Grosdani, Luca Felli, Raffaele Abete, Vincenzo Castiglione, Elisabetta Salvioni, Massimo Mapelli and 22 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open heart, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Piergiuseppe AgostoniCentro Cardiologico Monzino Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy piergiuseppe.agostoni@ccfm.it.ORCID http://orcid.org/0000-0002-8345-6382
Robin WillixhoferCentro Cardiologico Monzino Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy.
Arianna GalottaCentro Cardiologico Monzino Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy.
Filippo Maria RubboMonzino Cardiology Centre, Milan, Italy.
Stefano GrosdaniCentro Cardiologico Monzino, Monzino Cardiology Centre, Milan, Italy.
Luca FelliMonzino Cardiology Centre, Milan, Italy.
Raffaele AbeteCardiovascular Department, ASST Papa Giovanni XXIII, Bergamo, Italy.
Vincenzo CastiglioneScuola Superiore Sant'Anna, Pisa, Italy.
Elisabetta SalvioniCentro Cardiologico Monzino, Milano, Italy.
Massimo MapelliDepartment of Cardiovascular Sciences and Community Health, Centro Cardiologico Monzino, IRCCS, University of Milan, Milano, Italy.ORCID http://orcid.org/0000-0001-9985-7407
Carlo VignatiDepartment of Cardiovascular Sciences and Community Health, Centro Cardiologico Monzino, IRCCS, University of Milan, Milano, Italy.
Beatrice PezzutoHeart Failure Unit, Monzino Cardiology Centre, Milan, Italy.
Irene MattavelliHeart Failure Unit, Monzino Cardiology Centre, Milan, Italy.
Carriere CosimoCardiothoracovascular Department, University of Trieste, Trieste, Italy.
Nikita BaracchiniTreatment of Cardiomyopathies, Cardiovascular Department, University of Trieste, Trieste, Italy.
Teresa Maria CapovillaTreatment of Cardiomyopathies, Cardiovascular Department, University of Trieste, Trieste, Italy.
Claudio PassinoFondazione G. Monasterio CNR Regione Toscana, Pisa, Italy.
Anna ApostoloCentro Cardiologico Monzino Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy.
Pietro PalermoCentro Cardiologico Monzino Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy.
Jeness CampodonicoCentro Cardiologico Monzino Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy.
Mauro C ContiniCentro Cardiologico Monzino, Milano, Italy.
Lucia TricaricoUniversità degli Studi di Foggia, Foggia, Italy.
Emanuele BarbatoDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Emiliano FioriDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0001-8749-8558
Michele SenniAziende Socio Sanitarie Territoriale Papa Giovanni XXIII, Bergamo, Italy.
Damiano MagrìDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Annamaria IorioCardiovascular Department, ASST Papa Giovanni XXIII, Bergamo, Italy.
Susanna SciomerDepartment of Cardiology, La Sapienza University, Roma, Italy.
Michele CorrealeFoggia University Hospital, Foggia, Italy.
Gaia CattadoriUnità Operativa Cardiologia Riabilitativa, Ospedale S.Giuseppe, Multimedica Spa, IRCCS, Milan, Michigan, USA.ORCID http://orcid.org/0000-0002-0954-9871
Michele EmdinCardiovascular Medicine Division, Fondazione G. Monasterio CNR Regione Toscana, Pisa, Italy.
Gianfranco SinagraCardiovascular Department, University Health Authority Giuliano-Isontina, Trieste, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsCardiopulmonary exercise testing (CPET) parameters are used for heart failure (HF) prognostication. While the ventilation to carbon dioxide production (VE/VCO

methodsWe retrospectively analysed 2642 HF. Follow-up was 26 (9-63) months. The study endpoint was the composite of all-cause death, urgent transplant or left ventricular assist device implantation.

resultsMedian age was 62 (53-70) years and left ventricular ejection fraction (LVEF) 33% (27%-39%). 27% of patients were New York Heart Association class III-IV. During follow-up, 534 events occurred. Both VE/VCO

conclusionAn increase in the VE/VCO

Indexed as

Carbon DioxideExercise TestExercise ToleranceHeart FailureOxygen ConsumptionAgedChronic DiseaseFemaleFollow-Up StudiesHeart-Assist DevicesHeart TransplantationHumansMaleMiddle AgedPredictive Value of TestsPrognosisCarbon DioxideHEART FAILUREHeart Failure, SystolicRisk Factors

Identifiers

PMID42379661
PMCPMC13331205

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