Evidence map›Paper›PMID 42379655›Full record

ReviewJournal of neuroendocrinology2026

Controversies in NEN: An ENETS position statement on the interchangeability of somatostatin receptor PET tracers.

Christophe M Deroose, Valentina Ambrosini, Johannes Hofland, Gregory Kaltsas, Andreas Kjaer, Angela Lamarca, Anna Sowa-Staszczak, Eva Tiensuu Janson, Nicola Fazio

Erratum issuedAbstract readReviewConsensus Statement
In one paragraph

Review in Journal of neuroendocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Christophe M DerooseNuclear Medicine, University Hospitals Leuven & Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.ORCID https://orcid.org/0000-0002-6080-1577
Valentina AmbrosiniNuclear Medicine, Alma Mater Studiorum, University of Bologna, Bologna, Italy.ORCID https://orcid.org/0000-0002-5008-5351
Johannes HoflandDepartment of Internal Medicine, Section of Endocrinology, ENETS Center of Excellence, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.ORCID https://orcid.org/0000-0003-0679-6209
Gregory Kaltsas1st Department of Internal and Propaedeutic Medicine, EKPA LAIKO ENETS and EURACAN 4 Center of Excellence, National and Kapodistrian University of Athens, Athens, Greece.ORCID https://orcid.org/0000-0002-5876-7883
Andreas KjaerRigshospitalet, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-2706-5547
Angela LamarcaDepartment of Medical Oncology, Fundación Jiménez Díaz University Hospital, Health Research Institute-Fundación Jiménez Díaz University Hospital (IIS-FJD), Universidad Autónoma de Madrid (UAM), Madrid, Spain.ORCID https://orcid.org/0000-0001-9696-6122
Anna Sowa-StaszczakChair and Department of Endocrinology, Jagiellonian University Medical College, Krakow, Poland.ORCID https://orcid.org/0000-0001-7872-8833
Eva Tiensuu JansonDepartment of Medical Sciences, Endocrine Oncology, and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.ORCID https://orcid.org/0000-0002-1649-4880
Nicola FazioDivision of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, IEO, European Institute of Oncology IRCCS, Milan, Italy.ORCID https://orcid.org/0000-0001-6869-0704

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Molecular imaging of the somatostatin receptor (SSTR) plays a key role in the management of patients with neuroendocrine neoplasms in general, and neuroendocrine tumours in particular. Over the last 2 decades, gallium-68 labelled somatostatin analogues have revolutionised SSTR imaging through the advent of SSTR positron emission tomography (PET), leading to better staging and theranostic imaging. Recent advances in the development of PET SSTR tracers continue to change the field, with novel tracers labelled with different radionuclides such as fluorine-18 and copper-64, or based on new antagonist vector molecules. The advent of these innovations generates questions, such as which tracers can be used in clinical practice, how to compare scans performed with different tracers, or can antagonists be used to select patients for peptide receptor radionuclide therapy? This 'controversy paper' from the European Neuroendocrine Tumor Society provides an overview of the relevant evidence to answer these questions, and provides guidance to clinicians and nuclear medicine physicians for contemporary use of SSTR PET.

Indexed as

Neuroendocrine TumorsPositron-Emission TomographyRadiopharmaceuticalsReceptors, SomatostatinHumansRadiopharmaceuticalsReceptors, Somatostatinneuroendocrine tumourpositron emission tomography (PET)somatostatin receptor (SSTR)SSTR PETtracer

Identifiers

PMID42379655
PMCPMC13381107

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.