Norepinephrine attenuates acute lung injury by protecting mitochondria via the β

Yiyuan Yin, Zhaojin Zeng, Senhao Wei, Xiaoyun Wei, Zhukai Cong, Xi Zhu

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In one paragraph

Article in Redox biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

6 authors.

Yiyuan YinDepartment of Critical Care Medicine, Peking University Third Hospital, Beijing, China.

Zhaojin ZengDepartment of Critical Care Medicine, Peking University Third Hospital, Beijing, China.

Senhao WeiDepartment of Critical Care Medicine, Peking University Third Hospital, Beijing, China.

Xiaoyun WeiDepartment of Critical Care Medicine, Peking University Third Hospital, Beijing, China.

Zhukai CongDepartment of Anaesthesiology, Peking University Third Hospital, Beijing, China. Electronic address: bycongzhukai@bjmu.edu.cn.

Xi ZhuDepartment of Critical Care Medicine, Peking University Third Hospital, Beijing, China. Electronic address: xizhuccm@bjmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute lung injury (ALI) is a common and life-threatening critical illness with persistently high mortality, yet effective pharmacological therapies remain lacking. Norepinephrine (NE), a first-line vasopressor for septic shock, has been suggested to confer organ-protective and immunomodulatory effects in sepsis and related organ injury; however, its specific role and molecular mechanisms in ALI remain poorly defined. Here, we demonstrate both in vitro and in vivo that NE significantly attenuates ALI, and this protective effect is primarily attributable to the suppression of alveolar epithelial cell pyroptosis. Transcriptomic profiling and functional analyses reveal that NE activates the β

Indexed as

Acute Lung InjuryA Kinase Anchor ProteinsAlveolar Epithelial CellsMitochondriaNorepinephrinePyroptosisReceptors, Adrenergic, beta-2AnimalsHumansMiceSignal TransductionAkap1 protein, mouseA Kinase Anchor ProteinsNorepinephrineReceptors, Adrenergic, beta-2Acute lung injuryAKAP1Alveolar epithelial pyroptosisMitochondrial homeostasisNorepinephrine

Identifiers

PMID42378955

DOI10.1016/j.redox.2026.104283

PMCPMC13334398

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.