ReviewClinics (Sao Paulo, Brazil)2026
Effects of platelet-rich fibrin combined with hydroxyapatite in the treatment of patients with periodontal intrabony defects: a meta-analysis.
Review in Clinics (Sao Paulo, Brazil), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
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Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective of this meta-analysis was to systematically assess the effectiveness of Platelet-Rich Fibrin (PRF) in combination with Hydroxyapatite (HA) for the regenerative treatment of periodontal intrabony defects
methodsA systematic search was conducted across multiple databases, including PubMed, Web of Science, Cochrane Library, EMBASE, CNKI, and Wanfang, to identify Randomized Controlled Trials (RCTs) examining the combined use of PRF and HA for periodontal intrabony defects. Two independent researchers screened the literature according to inclusion and exclusion criteria, extracted data, and assessed the quality of the studies. Data analysis was performed using Stata 17.0 software.
resultsA total of 11 RCTs were included in the final meta-analysis. The meta-analysis indicated that the combination of PRF and HA significantly improved probing depth (MD = 0.74, 95% CI 0.32‒1.17, p < 0.001), clinical attachment loss (MD = 0.75, 95% CI 0.32‒1.19, p < 0.001), plaque index (MD = 0.05, 95% CI 0.00‒0.10, p = 0.03), and gingival index (MD = 0.13, 95% CI 0.01‒0.25, p = 0.04) in the treatment of periodontal intrabony defects.
conclusionThe combination of platelet-rich fibrin and hydroxyapatite appears to be an effective approach for treating periodontal intrabony defects. However, due to the limited number and quality of the included studies, further research with high-quality, large-scale trials is necessary to validate these findings.
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