ArticlePregnancy hypertension2026
Leptin levels in mid-pregnancy and risk of preeclampsia.
Article in Pregnancy hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundOur objective was to examine the association between mid-pregnancy leptin concentration and preeclampsia risk, adjusting for maternal risk factors.
methodsWe studied 1504 women with singleton pregnancies in the Project Viva cohort. The exposure was mid-pregnancy plasma leptin concentration (mean gestational age 28 weeks), categorized into tertiles. The primary outcome was preeclampsia during that pregnancy. The secondary outcome was self-reported preeclampsia during subsequent pregnancies. We used multivariable logistic regression to assess the association of leptin tertiles with preeclampsia, adjusting for pre-pregnancy BMI, first trimester gestational weight gain, history of hypertension, age, and parity.
resultsThere were two (0.4%) cases of preeclampsia among participants in the lowest leptin tertile, 20 (4.0%) in the middle tertile, and 29 (5.8%) in the highest tertile. Higher leptin levels were associated with higher odds of preeclampsia after adjustment for confounders. Compared to the lowest tertile, odds ratios were 7.5 (95% CI 1.7, 32.7) for the middle tertile and 7.0 (95% CI 1.5, 31.9) for the highest tertile. Higher leptin levels were also associated with higher odds of preeclampsia in subsequent pregnancies (6.1% vs 0.9% in the middle vs. lowest tertile, OR 6.4, 95% CI 0.7, 57.0), although the estimates were highly imprecise due to the small sample size.
conclusionsHigher mid-pregnancy leptin concentrations were associated with increased risk of preeclampsia, independent of maternal age, pre-pregnancy BMI, first trimester gestational weight gain, history of hypertension, and parity. Additionally, our results suggest that elevated leptin during a prior pregnancy may increase preeclampsia risk in subsequent pregnancies.
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