Evidence map›Paper›PMID 42378671›Full record

ArticleJMIR formative research2026

Knowledge Graphs Based on Meta-Analysis Papers Improve the Quality of Case Formulation: Mixed Methods Design.

Kenji Yokotani, Yasumitsu Jikihara, Kohei Koiwa

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Article in JMIR formative research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

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3 authors.

Kenji YokotaniGraduate School of Technology, Industrial and Social Sciences, Tokushima University, 1-1, Minamijosanjima-cho, Tokushima, 770-8502, Japan, 81 88-656-7000.ORCID 0000-0002-9711-157X
Yasumitsu JikiharaGraduate School of Human Sciences, The University of Osaka, Suita, Japan.ORCID 0000-0001-5267-4144
Kohei KoiwaGraduate School of Education, Hokkaido University of Education, Sapporo, Japan.ORCID 0000-0002-1013-7778

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Case formulation (CF) is a core skill for therapists; however, creating high-quality CFs requires considerable time. Objective: This study aims to demonstrate that providing a knowledge graph based on meta-analytic literature can enhance CF quality. Methods: Five groups were established, including 4 large language model groups and 1 human expert group, each generating 25 CFs based on 25 vignettes. The control group with Claude (Sonnet 3.7; Anthropic) produced 25 CFs. The personalization group served as the control group with additional personalization prompts. The knowledge graph group used a large language model that generated 25 CFs, which was provided with a meta-analysis knowledge graph. Further incorporation of additional personalization prompts then comprised the knowledge graph with personalization group. Finally, the expert group consisted of 25 CFs generated by a human expert. These 125 CFs in total were evaluated for general quality (ie, correctness, completeness, feasibility, and consistency) using a 7-point scale and 18 essential elements with binary scores (0 or 1) by another human expert. The CFs were also qualitatively analyzed. Results: The knowledge graph and knowledge graph with personalization groups scored significantly higher than the control group in terms of correctness, completeness, and feasibility. The expert group scored significantly higher on consistency than the machine-generated groups. Additionally, there was no significant difference in the feasibility scores among the knowledge graph, knowledge graph with personalization, and expert groups. The qualitative evaluation suggested that human CFs narrow the text to content that is easy for the client to read, whereas machine CFs are more likely to include expressions that are unnatural to the client. Conclusions: These results indicate that providing knowledge graphs to novice therapists increases the correctness, completeness, and feasibility of CF. Providing experienced therapists with knowledge graphs is suggested to improve the quality of their CF and mental health services.

Indexed as

Meta-Analysis as TopicHumansLarge Language Modelscase formulationfamily therapyknowledge graphlarge language modelLLMreframing

Identifiers

PMID42378671
PMCPMC13318205

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.