Evidence map›Paper›PMID 42378627›Full record

Trial reportJournal of the American Geriatrics Society2026

Perioperative Transfusion Trigger Score Versus Restrictive Transfusion in Older Non-Cardiac Surgery Patients: A Multicenter Randomized Controlled Trial.

Shucong Liang, Lijuan Bai, Guizhen Yang, Zhuo Chen, Yujia Wei, Yanxia Wei, Yuting Lv, Zehan Huang, Yanjuan Huang, Kejian Lu

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Geriatrics Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shucong LiangDepartment of Anesthesiology, The Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Lijuan BaiDepartment of Anesthesiology, The Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Guizhen YangDepartment of Anesthesiology, The Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Zhuo ChenDepartment of Anesthesiology, The Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Yujia WeiDepartment of Anesthesiology, The Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Yanxia WeiDepartment of Anesthesiology, The Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Yuting LvDepartment of Anesthesiology, The Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Zehan HuangDepartment of Anesthesiology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China.
Yanjuan HuangDepartment of Anesthesiology, The Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.ORCID https://orcid.org/0000-0003-0744-9727
Kejian LuDepartment of Anesthesiology, The Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.ORCID https://orcid.org/0000-0001-6226-2602

Funding

Nanning Science and Technology Foundation 20233068
6 · The paper itself

Abstract

backgroundRestrictive transfusion (Hb < 7 g/dL) is recommended for most perioperative patients, but the optimal threshold for those with cardiovascular disease or Hb 7-10 g/dL remains uncertain. The Perioperative Transfusion Trigger Score (POTTS), which integrates adrenaline requirement, FiO

methodsThis multicenter RCT in two Chinese hospitals randomized patients ≥ 60 years undergoing non-cardiac surgery 1:1 to POTTS or control. POTTS = 6 plus points for adrenaline, FiO PRIMARY OUTCOME: proportion receiving allogeneic RBC transfusion during perioperative period (ITT population).

results253 patients (mean age 72.3 years; 67.6% women) were randomized (May 2023-Sept 2025). Baseline Hb similar (median 9.60 vs. 9.50 g/dL). In ITT, transfusion required in 24.00% (30/125) of POTTS vs. 35.94% (46/128) of control (p = 0.038). Transfusion volume did not differ significantly (median 2.50 vs. 3.00 units, p = 0.520). Overall complication rates: 12.80% vs. 8.59% (p = 0.279); one death in control group (0.85%). No significant differences in specific complications.

conclusionIn patients ≥ 60 years undergoing non-cardiac surgery, POTTS-guided transfusion significantly reduced the proportion of patients transfused without increasing complications.

trial registrationThis study was registered at http://www.chictr.org.cn (#ChiCTR2300071739).

Indexed as

Blood TransfusionErythrocyte TransfusionPerioperative CareSurgical Procedures, OperativeAgedAged, 80 and overChinaFemaleHemoglobinsHumansMaleMiddle AgedHemoglobinsblood transfusionolder patientsperioperative transfusion trigger scorerestrictive transfusion strategy

Identifiers

PMID42378627
PMCPMC13589669

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.