Evidence map›Paper›PMID 42378620›Full record

ReviewInternational journal of radiation biology2026

Biochemical, structural and mutational landscapes of base excision repair enzymes and cancer: from atomic resolution to tumor signatures.

Simone Hall, Cameron Cordero, Mohammad Hashemian, Marcos B Ngo, Sheila S David, Steven A Roberts, Joann B Sweasy, Sylvie Doublié

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of radiation biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Simone HallEppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0002-7538-5588
Cameron CorderoDepartment of Microbiology and Molecular Genetics, The University of Vermont, Burlington, VT, USA.
Mohammad HashemianDepartment of Chemistry, University of California, Davis, CA, USA.
Marcos B NgoDepartment of Microbiology and Molecular Genetics, The University of Vermont, Burlington, VT, USA.
Sheila S DavidDepartment of Chemistry, University of California, Davis, CA, USA.ORCID 0000-0001-5873-7935
Steven A RobertsDepartment of Microbiology and Molecular Genetics, The University of Vermont, Burlington, VT, USA.ORCID 0000-0002-3628-5808
Joann B SweasyEppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0002-4503-0284
Sylvie DoubliéDepartment of Microbiology and Molecular Genetics, The University of Vermont, Burlington, VT, USA.ORCID 0000-0002-6294-5304

Funding

SUBSTRATE SPECIFICITY OF THE BER OXIDATIVE DNA GLYCOSYLASESP01CA098993 · NCI · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI LEE, ANDREA J · 2004 to 2021
$25.9M
Genome-wide analysis of the formation and mutagenesis of atypical UV photoproducts in skin cancerR01ES032814 · NIEHS · WASHINGTON STATE UNIVERSITY · PI STEVEN A ROBERTS, John J Wyrick · 2021 to 2026
$5.8M
RECOGNITION AND REPAIR OF MISMATCHED DNA BY MUTYR01CA067985 · NCI · UNIVERSITY OF UTAH · PI DAVID, SHEILA SUE · 2000 to 2025
$5.6M
Aberrant DNA Repair and LupusR35ES031708 · NIEHS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Joann B. Sweasy · 2020 to 2026
$5.3M
Regulation of APOBEC3 cytidine deaminase-induced mutation during cancerdevelopmentR01CA269784 · NCI · WASHINGTON STATE UNIVERSITY · PI STEVEN A ROBERTS · 2023 to 2026
$2.0M
Fidelity Mechanisms of DNA Polymerase BetaR01CA281044 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Sylvie Doublie, JOSEPH P LORIA · 2024 to 2026
$1.9M
NCI NIH HHS P01 CA098993NCI NIH HHS R01 CA067985NCI NIH HHS R01 CA269784NCI NIH HHS R01 CA281044NIEHS NIH HHS R01 ES032814NIEHS NIH HHS R35 ES031708
6 · The paper itself

Abstract

purposeBase excision repair (BER) is the predominant pathway for repairing non‑bulky oxidized and alkylated DNA base lesions, and its fidelity depends on the coordinated action of lesion‑specific DNA glycosylases and downstream repair enzymes. This review aims to summarize recent structural, biochemical, and genomic insights into three base excision repair enzymes, MUTYH DNA glycosylase, NTHL1 DNA glycosylase, and DNA polymerase β.

conclusionThis review outlines how MUTYH, NTHL1 and DNA polymerase β protect the genome from mutagenesis, highlights major germline variants associated with disease, and synthesizes the current knowledge on the characteristic single base substitution (SBS) mutational signatures that occur when these repair enzymes are dysfunctional.

Indexed as

Base excision repairDNA glycosylaseDNA polymerase betagermline variantsingle base substitution signaturevariant of uncertain significance

Identifiers

PMID42378620
PMCPMC13616231

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.