Evidence map›Paper›PMID 42378535›Full record

ArticleThe journal of international advanced otology2025

Audio-Vestibular Function in Patients Diagnosed with Lyme Neuroborreliosis.

Elisa Skovgaard Jensen, Jonas Bruun Kjærsgaard, Per Cayé-Thomasen, Dan Dupont Hougaard, Nicolas Lyneborg, Christian Thomas Brandt, Malene Kirchmann

Abstract read
In one paragraph

Article in The journal of international advanced otology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Elisa Skovgaard JensenDepartment of Otorhinolaryngology, North Zealand Hospital, University of Copenhagen, Hillerød, Denmark.ORCID 0000-0001-5705-1560
Jonas Bruun KjærsgaardDepartment of Otolaryngology, Head & Neck Surgery and Audiology, Aalborg University Hospital, Aalborg, Denmark.ORCID 0000-0001-7332-9024
Per Cayé-ThomasenDepartment of Otorhinolaryngology Head & Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Denmark.ORCID 0000-0002-6837-694X
Dan Dupont HougaardDepartment of Otolaryngology, Head & Neck Surgery and Audiology, Aalborg University Hospital, Aalborg, Denmark.ORCID 0000-0002-4164-1758
Nicolas LyneborgDepartment of Otorhinolaryngology, North Zealand Hospital, University of Copenhagen, Hillerød, Denmark.ORCID 0009-0001-4367-7973
Christian Thomas BrandtDepartment of Clinical Medicine, University of Copenhagen Faculty of Health and Medical Sciences, Copenhagen, Denmark.ORCID 0000-0003-0201-0440
Malene KirchmannDepartment of Otorhinolaryngology, North Zealand Hospital, University of Copenhagen, Hillerød, Denmark.ORCID 0000-0001-9193-1609

Funding

Helene Rudes FoundationJascha FoundationKaptain Løjtnant Harald Jensen og Hustrus FoundationNordsjællands Hospital FoundationOticon FoundationTvergaards Foundation
6 · The paper itself

Abstract

backgroundThis study assessed the audio-vestibular function and symptoms in patients diagnosed with Lyme neuroborreliosis (LNB).

methodsPatients with LNB were included prospectively. Diagnosis was based on a cerebrospinal fluid leukocyte count ≧ 10 × 106 cells/L and a positive blood antibody production or intrathecal Borrelia burgdorferi antibody titer together with symptoms of LNB. Vestibular assessments included video head impulse test and a caloric test. Hearing was assessed by pure-tone audiometry at discharge and 30 days after hospitalization and compared to a healthy age- and sex-matched control dataset. Symptoms were assessed by a structured interview and the Dizziness Handicap Inventory (DHI).

resultsNineteen patients were included in the study. Four (21%) patients had vestibular dysfunction; 2 were unilateral and 2 were bilateral. The lateral semicircular canal was dysfunctional in 3 patients, the anterior semicircular canal in 2 patients, and the posterior semicircular canal in 1 patient. Sensorineural hearing loss, defined by audiometry, was present in 9 (47%) patients according to the audiometry at discharge and 10 (59%) patients during the follow-up audiometry. Hearing did not differ significantly from the age- and sex-matched control dataset. Vestibular dysfunction was not significantly associated with the total DHI score or with the mean PTA (Pure tone audiometry). The most commonly reported symptoms were peripheral nerve palsy (47%), dizziness (32%), fatigue (32%) and headache (32%).

conclusionAudio-vestibular function was affected in patients with LNB but correlated poorly with the patients' self-reported audio-vestibular symptoms.

Indexed as

Hearing Loss, SensorineuralLyme NeuroborreliosisVestibular DiseasesAdultAgedAudiometry, Pure-ToneAuditory AcuityBorrelia burgdorferiCaloric TestsDizzinessFemaleHead Impulse TestHumansMaleMiddle AgedProspective StudiesCentral nervous system infectionLyme neuroborreliosisotologysensorineural hearing lossvestibular diseases

Identifiers

PMID42378535
PMCPMC12520149

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.