ReviewJournal of immunology (Baltimore, Md. : 1950)2026
Getting on your last nerve: IFNs and resistance to infection.
Review in Journal of immunology (Baltimore, Md. : 1950), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Authors and funding
2 authors.
Funding
Abstract
Interferons (IFNs) affect almost all nucleated cells and induce transcriptional events that are associated with control of intracellular infections as well as regulatory pathways that influence inflammatory processes. How different hematopoietic and non-hematopoietic cell types interpret these signals is a reflection of cellular context and function. For example, neurons are often viewed as immunologically inert and have muted responses to IFNs. However, because neurons can be targeted by several classes of pathogens, there is a need for these cells to sense infection and respond to IFNs to engage anti-microbial activities. This review discusses the unique features of neuronal IFN signaling, emphasizing how JAK-STAT pathway engagement and downstream induction of interferon-stimulated genes (ISGs) shape intrinsic and extrinsic neuronal anti-pathogen defense.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.