ArticleJournal of the American Chemical Society2026
Iterative Bump-and-Hole Engineering Creates a Bioorthogonal Reporter for
Yu Liu, Saskia Pieters, Ganka Bineva-Todd, Mert Sagiroglugil, Sean A Burnap, Freya Hoddle, Anna Cioce, Andre Ohara, Sophie D Schmidt, Kevin Bruemmer and 5 more
Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Yu LiuDepartment of Chemistry, Imperial College London, W12 0BZ London, United Kingdom.
Saskia PietersDepartment of Chemistry, Imperial College London, W12 0BZ London, United Kingdom.
Ganka Bineva-ToddChemical Glycobiology Laboratory, The Francis Crick Institute, NW1 1AT London, United Kingdom.
Mert SagiroglugilDepartament de Química Inorgànica i Orgànica (Secció de Química Orgànica) and Institut de Química Teòrica i Computacional (IQTCUB), Universitat de Barcelona, 08028 Barcelona, Spain.ORCID 0000-0002-4714-3717
Sean A BurnapDepartment of Biochemistry, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford OX1 3QU, United Kingdom.
Freya HoddleDepartment of Chemistry, Imperial College London, W12 0BZ London, United Kingdom.
Anna CioceDepartment of Chemistry, Imperial College London, W12 0BZ London, United Kingdom.
Andre OharaDepartment of Chemical Engineering, Imperial College London, London SW7 2AZ, United Kingdom.
Sophie D SchmidtDepartment of Chemistry, Imperial College London, W12 0BZ London, United Kingdom.ORCID 0009-0009-9349-4997
Kevin BruemmerStanford Sarafan ChEM-H, Stanford University, Stanford, California 94305, United States.
Carolyn R BertozziStanford Sarafan ChEM-H, Stanford University, Stanford, California 94305, United States.ORCID 0000-0003-4482-2754
Karen PolizziDepartment of Chemical Engineering, Imperial College London, London SW7 2AZ, United Kingdom.ORCID 0000-0001-5435-2667
Weston B StruweDepartment of Biochemistry, Dorothy Crowfoot Hodgkin Building, University of Oxford, Oxford OX1 3QU, United Kingdom.ORCID 0000-0003-0594-226X
Carme RoviraDepartament de Química Inorgànica i Orgànica (Secció de Química Orgànica) and Institut de Química Teòrica i Computacional (IQTCUB), Universitat de Barcelona, 08028 Barcelona, Spain.ORCID 0000-0003-1477-5010
Benjamin SchumannDepartment of Chemistry, Imperial College London, W12 0BZ London, United Kingdom.ORCID 0000-0001-5504-0147
Funding
ZINC DEFICIENCY &PROTEIN EXPRESSION IN RAT OLFACTORY BULBSP41RR005351 · NCRR · UNIVERSITY OF GEORGIA (UGA) · PI AZADI, PARASTOO · 1989 to 2011
$18.4M
NCRR NIH HHS P41 RR005351Wellcome Trust CC2127
6 · The paper itself
Abstract
Asparagine-linked protein glycosylation is among the most frequent modifications of proteins trafficking through the secretory pathway. These glycans are manufactured in an assembly line process, yielding a common precursor that is then subjected to individual modifications with different levels of complexity. An important biosynthetic modulator is the incorporation of
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Iterative Bump-and-Hole Engineering Creates a Bioorthogonal Reporter for · full record | OpenQuestion