Evidence map›Paper›PMID 42378402›Full record

ArticleJournal of cardiovascular electrophysiology2026

Influence of High-Frequency Low-Tidal Volume Versus Jet Ventilation on Acute and Long-Term Outcomes Following Pulmonary Vein Isolation.

Daniel Villarreal, Juliana Perez-Pinzon, Andre d'Avila, Peter Zimetbaum, Andrew H Locke, Shu Yang, Timothy Maher, Sankalp Sehgal, Maximilian S Schaeffer, Sebastian D Sahli and 2 more

Abstract readComparative Study
In one paragraph

Article in Journal of cardiovascular electrophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Daniel VillarrealHarvard-Thorndike Arrhythmia Institute, Beth Israel Deaconess Medical Center, Division of Cardiovascular Medicine, Boston, Massachusetts, USA.ORCID 0000-0002-9719-4870
Juliana Perez-PinzonDepartment of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
Andre d'AvilaHarvard-Thorndike Arrhythmia Institute, Beth Israel Deaconess Medical Center, Division of Cardiovascular Medicine, Boston, Massachusetts, USA.
Peter ZimetbaumHarvard-Thorndike Arrhythmia Institute, Beth Israel Deaconess Medical Center, Division of Cardiovascular Medicine, Boston, Massachusetts, USA.
Andrew H LockeHarvard-Thorndike Arrhythmia Institute, Beth Israel Deaconess Medical Center, Division of Cardiovascular Medicine, Boston, Massachusetts, USA.
Shu YangHarvard-Thorndike Arrhythmia Institute, Beth Israel Deaconess Medical Center, Division of Cardiovascular Medicine, Boston, Massachusetts, USA.
Timothy MaherHarvard-Thorndike Arrhythmia Institute, Beth Israel Deaconess Medical Center, Division of Cardiovascular Medicine, Boston, Massachusetts, USA.
Sankalp SehgalDepartment of Anesthesiology, Boston Medical Center, Boston, Massachusetts, USA.
Maximilian S SchaefferDepartment of Anesthesia & Critical Care, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Sebastian D SahliDepartment of Anesthesia & Critical Care, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Jonathan W WaksHarvard-Thorndike Arrhythmia Institute, Beth Israel Deaconess Medical Center, Division of Cardiovascular Medicine, Boston, Massachusetts, USA.
Patricia TungHarvard-Thorndike Arrhythmia Institute, Beth Israel Deaconess Medical Center, Division of Cardiovascular Medicine, Boston, Massachusetts, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionUse of high-frequency low-tidal volume (HFLTV) and high-frequency jet ventilation (HFJV) during pulmonary vein isolation (PVI) improves acute procedural success and long-term outcomes compared to conventional ventilation. However, the impact of HFLTV compared to HFJV on acute and long-term outcomes is unknown.

methodsWe prospectively identified 1039 patients who underwent first-time PVI or PVI with posterior wall isolation (PWI) at our institution between 2022 and 2024 with HFLTV or HFJV. Acute procedural and safety outcomes were analyzed. Twelve-month arrhythmia-free survival was evaluated using the Kaplan-Meier and Cox proportional hazards method.

resultsAfter excluding 44 patients who required discontinuation of HFJV, 860 patients receiving HFJV were compared with 179 receiving HFLTV ventilation. Mean age was 65 years, 93% were White, 30% female and 53% had paroxysmal AF. First-pass isolation (FPI) rates were similar between ventilation strategies. HFLTV was associated with a higher rate of intraprocedural hypotension (31% vs 23%, p = 0.02). Complications were generally minor and comparable between groups. Arrhythmia recurrence rates at 12 months were similar (HR: 0.89, p = 0.55). There was a trend toward improved outcomes when FPI was achieved for both pulmonary veins in either group.

conclusionIn this observational cohort, no significant differences in acute procedural outcomes, safety outcomes, or long-term arrhythmia recurrence were observed between HFLTV and HFJV. Given the specialized equipment and operator training required for HFJV and its non-negligible rate of discontinuation, HFLTV may offer a modest practical advantage in routine clinical practice.

Indexed as

Atrial FibrillationCatheter AblationHigh-Frequency Jet VentilationPulmonary VeinsTidal VolumeAction PotentialsAgedFemaleHumansMaleMiddle AgedProgression-Free SurvivalProspective StudiesRecurrenceRisk FactorsTime Factorsatrial fibrillationfirst‐pass isolationhigh‐frequency jet ventilationhigh‐frequency low tidal volumepulmonary vein isolationradiofrequency ablation

Identifiers

PMID42378402
PMCPMC13576561

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.