Evidence map›Paper›PMID 42378301›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Tau protein as a regulator of mitochondrial function and dynamics.

Eleni Tsakiri, Carlos Campos-Marques, Christina Ploumi, Kalliopi Skourti, Antonis Roussos, Eirini Mytilinaiou, Anastasia Vamvaka Iakovou, Ildete Luísa Ferreira, Chrysoula Dioli, Despoina D Gianniou and 9 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Eleni TsakiriDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece.
Carlos Campos-MarquesLife and Health Sciences Research Institute (ICVS), University of Minho, Braga 4710-057, Portugal.ORCID 0000-0002-0612-4333
Christina PloumiDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece.ORCID 0000-0002-2389-5471
Kalliopi SkourtiLaboratory of Brain exosomes and Pathology - ExoBrain, Institute of Biosciences and Applications, National Centre for Scientific Research Demokritos, Agia Paraskevi 15341, Greece.
Antonis RoussosDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece.ORCID 0009-0006-1101-7301
Eirini MytilinaiouDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece.
Anastasia Vamvaka IakovouLaboratory of Brain exosomes and Pathology - ExoBrain, Institute of Biosciences and Applications, National Centre for Scientific Research Demokritos, Agia Paraskevi 15341, Greece.ORCID 0000-0003-2031-9337
Ildete Luísa FerreiraCenter for Neuroscience and Cell Biology, University of Coimbra, Coimbra 3004-504, Portugal.ORCID 0000-0001-6552-4479
Chrysoula DioliLife and Health Sciences Research Institute (ICVS), University of Minho, Braga 4710-057, Portugal.
Despoina D GianniouDepartment of Biology, National and Kapodistrian University of Athens, Athens 15784, Greece.ORCID 0000-0002-8111-6528
Martina SamiotakiBiomedical Sciences Research Center "Alexander Fleming", Institute for Bio-innovation, Vari 16672, Greece.ORCID 0000-0001-9952-0636
Jonas CamposLife and Health Sciences Research Institute (ICVS), University of Minho, Braga 4710-057, Portugal.
Clarissa WaitesDepartment of Pathology and Cell Biology, Taub Institute for Research on Alzheimer's Disease and Aging Brain, Columbia University Irving Medical Center, New York, NY 10032.
Nuno SousaCentro Universitário de Jaguariúna, São Paulo 13918-112, Brazil.ORCID 0000-0002-8755-5126
Ioannis P TrougakosDepartment of Biology, National and Kapodistrian University of Athens, Athens 15784, Greece.ORCID 0000-0002-6179-2772
Joana M SilvaLife and Health Sciences Research Institute (ICVS), University of Minho, Braga 4710-057, Portugal.ORCID 0000-0002-8257-3413
A Cristina RegoCenter for Neuroscience and Cell Biology, University of Coimbra, Coimbra 3004-504, Portugal.ORCID 0000-0003-0700-3776
Ioannis SotiropoulosLife and Health Sciences Research Institute (ICVS), University of Minho, Braga 4710-057, Portugal.
Konstantinos PalikarasDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece.ORCID 0000-0001-6992-5560

Funding

COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation and Portuguese national funds via FCT - Fundação para a Ciência e a Tecnologia, UIDB/04539/2020EC | Horizon Europe | Excellent Science | HORIZON EUROPE European Research Council (ERC) 101077374Fondation Sante 19656Hellenic Foundation for Research and Innovation (H.F.R.I.) 15493National Recovery and Resilience plan Greece 2.0, funded by the European Union - NextGenerationEU TAEDR-0535850NIH grant 4R01AG069941-02the Greece 2.0, National Recovery and Resilience Plan Flagship program TAEDR-0535850The Greek Research Infrastructure for Personalized Medicine (pMED-GR) MIS 5002802
6 · The paper itself

Abstract

Mitochondrial damage is a shared hallmark of brain aging and neurodegeneration. While pathological Tau mutations disrupt mitochondrial dynamics and function, the physiological role of wild-type (WT) Tau in the maintenance of mitochondrial homeostasis remains poorly understood. Here, using

Indexed as

Caenorhabditis elegans ProteinsMitochondriaMitochondrial Dynamicstau ProteinsAnimalsCaenorhabditis elegansGTP PhosphohydrolasesHomeostasisMiceMice, KnockoutCaenorhabditis elegans ProteinsFZO-1 protein, C elegansGTP Phosphohydrolasestau Proteinsmitochondriamitochondrial dynamicsneurodegenerationneuronTau

Identifiers

PMID42378301
PMCPMC13342828

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.