ArticleProceedings of the National Academy of Sciences of the United States of America2026
Phosphatidylinositol diphosphate binding by ESCRT-III filaments.
Akram Alian, John McCullough, Frank R Moss, Nathaniel Talledge, Arshad Mohammed, Cecilia D Gerstner, Jacob A Dalluge, Elliott L Paine, Omar Davulcu, Chi-Lun Chang and 2 more
Abstract read
In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
12 authors.
Akram Alian *Department of Biochemistry, University of Utah Spencer Fox Eccles School of Medicine, Salt Lake City, UT 84112.
John McCullough *Department of Biochemistry, University of Utah Spencer Fox Eccles School of Medicine, Salt Lake City, UT 84112.
Frank R Moss *Discovery Science, Altos Labs, Redwood City, CA 94065.
Nathaniel TalledgeDiscovery Science, Altos Labs, Redwood City, CA 94065.
Arshad MohammedDiscovery Science, Altos Labs, Redwood City, CA 94065.
Cecilia D GerstnerDepartment of Biochemistry, University of Utah Spencer Fox Eccles School of Medicine, Salt Lake City, UT 84112.
Jacob A DallugeDepartment of Biochemistry, University of Utah Spencer Fox Eccles School of Medicine, Salt Lake City, UT 84112.
Elliott L PaineDepartment of Biochemistry, University of Utah Spencer Fox Eccles School of Medicine, Salt Lake City, UT 84112.
Omar DavulcuPacific Northwest Center for Cryoelectron Microscopy, Oregon Health & Science University, Portland, OR 97201.
Chi-Lun ChangDepartment of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105.ORCID 0000-0003-0017-2243 Adam FrostDiscovery Science, Altos Labs, Redwood City, CA 94065.
Wesley I SundquistDepartment of Biochemistry, University of Utah Spencer Fox Eccles School of Medicine, Salt Lake City, UT 84112.ORCID 0000-0001-9988-6021 Funding
Pacific Northwest Center for Cryo-EM: Equipment SupplementR24GM154185 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI James E Evans, CLAUDIA SUSANA LOPEZ · 2024 to 2026
$21.5MBiochemistry of HIV-1 BuddingR37AI051174 · NIAID · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI WESLEY I. SUNDQUIST · 2017 to 2026
$5.6MESCRT-III and MIT Protein Complexes in CytokinesisR01GM112080 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI CHRISTOPHER P. HILL, WESLEY I. SUNDQUIST · 2014 to 2026
$4.1MLINEAR ION-TRAP /FOURIER TRANSFORM MASS SPECTROMETER: PROTEOMICS: DIABETESS10RR020883 · NCRR · UNIVERSITY OF UTAH · PI NELSON, CHAD P · 2005 to 2005
$500kMaldi/ToF/ToF Mass Spectrometer for the University of UtahS10RR025532 · NCRR · UNIVERSITY OF UTAH · PI NELSON, CHAD C · 2010 to 2010
$490kHHS | NIH (NIH) NIH R37 AI051174HHS | NIH (NIH) R24GM154185HHS | NIH (NIH) S10 RR020883-01 and 1 S10 RR025532-01A1NCRR NIH HHS S10 RR020883NCRR NIH HHS S10 RR025532NIAID NIH HHS R37 AI051174NIGMS NIH HHS R01 GM112080NIGMS NIH HHS R24 GM154185
6 · The paper itselfAbstract
Different inositol phospholipids (PIPs) distribute to distinct subcellular organelles, creating an addressing system that dictates the sites of action of PIP-binding proteins, including components of the Endosomal Sorting Complexes Required for Transport (ESCRT). The ESCRT machinery is recruited to remodel many different cellular membranes through combinatorial binding interactions made by the early-acting ESCRT-I and ESCRT-II complexes with PIPs, ubiquitin modifications, and membrane-specific adaptors. Membrane remodeling, constriction, and fission are then mediated by membrane-associated filaments formed by subunits of the late-acting ESCRT-III complexes, together with their associated VPS4 AAA ATPases. Here, we describe two different classes of helical ESCRT-III filaments that can surround and tubulate membranes containing PIP
Indexed as
Endosomal Sorting Complexes Required for TransportPhosphatidylinositol 4,5-DiphosphateSaccharomyces cerevisiae ProteinsCell MembraneCryoelectron MicroscopyModels, MolecularProtein BindingSaccharomyces cerevisiaeEndosomal Sorting Complexes Required for TransportPhosphatidylinositol 4,5-DiphosphateSaccharomyces cerevisiae ProteinsEndosomal Sorting Complexes Required for Transport (ESCRT)ESCRT-III filamentsmembrane remodelingphosphatidylinositols
Identifiers
PMID42378278
PMCPMC13342873
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