Evidence map›Paper›PMID 42377826›Full record

ArticleMolecular diversity2026

Discovery of novel perillyl and myrtenyl nucleobase conjugates as dual anti-Alzheimer and antimicrobial agents.

Saida Lachhab, Soukaina Elmoussaoui, Meriem Rafya, Az-Eddine El Mansouri, Ahmad Mehdi, Raquel R Ramalhosa, Ana R Costa, Elisabete P Carreiro, Graciela Andrei, Robert Snoeck and 4 more

Abstract read
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In one paragraph

Article in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Saida LachhabLaboratory of Molecular Chemistry, Department of Chemistry, Faculty of Sciences Semlalia, 40000, Marrakech, Morocco.
Soukaina ElmoussaouiLaboratory of Molecular Chemistry, Department of Chemistry, Faculty of Sciences Semlalia, 40000, Marrakech, Morocco.
Meriem RafyaLaboratoire de Recherche en développement durable et santé, Faculty of Sciences and Technology Gueliz (FSTG), BP54940000, Marrakech, Morocco.
Az-Eddine El MansouriLaboratoire Biotechnologie, Agroalimentaire, Matériaux et Environnement Faculty of Sciences and Technology Mohammedia (FSTM), Mohammedia, Morocco.
Ahmad MehdiCNRS, ENSCM, ICGM, University Montpellier, Montpellier, France.
Raquel R RamalhosaDepartment of Chemistry and Biochemistry, School of Science and Technology, University of Évora, Évora, Portugal.
Ana R CostaDepartment of Medical and Health Sciences, School of Health and Human Development, University of Évora, Évora, Portugal.
Elisabete P CarreiroLAQV-REQUIMTE-Polo de University of Évora, Institute for Research and Advanced Training (IIFA), University of Évora, Rua Romão Ramalho, 59, 7000, Évora, Portugal. betepc@uevora.pt.
Graciela AndreiRega Institute for Medical Research, KU Leuven, Louvain, Belgium.
Robert SnoeckRega Institute for Medical Research, KU Leuven, Louvain, Belgium.
Fatiha BenkhaltiLaboratoire de Recherche en développement durable et santé, Faculty of Sciences and Technology Gueliz (FSTG), BP54940000, Marrakech, Morocco.
Yogesh S SanghviRasayan Inc., 2802 Crystal Ridge Road, Encinitas, CA, 92024-6615, USA.
Mustapha Ait AliLaboratory of Molecular Chemistry, Department of Chemistry, Faculty of Sciences Semlalia, 40000, Marrakech, Morocco.
Hassan B LazrekLaboratory of Molecular Chemistry, Department of Chemistry, Faculty of Sciences Semlalia, 40000, Marrakech, Morocco. hblazrek50@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies suggest that Alzheimer's disease may be influenced by microbial infections and may involve multiple microbial pathogens contributing to its development and progression. Based on this hypothesis, dual antimicrobial and anti-Alzheimer's agents may provide advantages such as improved therapeutic effectiveness, treatment of infection-related Alzheimer disease, and reduced toxicity compared with single-target drugs. To discover novel therapeutic agents, a series of terpene-substituted pyrimidine derivatives were synthesized and evaluated for their antiviral, antibacterial, antifungal and anti-Alzheimer's activities. All compounds were characterized by spectroscopic methods to support their structures. Among all compounds screened for their biological activity, compounds 11 and 32 displayed excellent IC50 values of 10.1 and 9.9 µM, respectively, against eqBChE in comparison with Food and Drug Administration (FDA)-approved drugs galantamine (IC

Indexed as

AntibacterialAnti-cholinesterasesAntifungalAntiviralCatalyst NH4I@g-C3N4Terpenic carboacyclic nucleoside analogs

Identifiers

PMID42377826

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.