FGFR3::TACC3 Fusion and NOTCH1 Loss-of-Function in a Case of HPV-Associated Sinonasal Squamous Cell Carcinoma: Diagnostic Challenge and Implications for Targeted Therapy.

Xu Cao, Hong Yu, Reham Hamdy Abdulazim Soliman, Pei Ying, Songlin Zhang, Li Liang

Abstract readCase Reports

In one paragraph

Article in Head and neck pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Xu CaoDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.

Hong YuDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.

Reham Hamdy Abdulazim SolimanDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.

Pei YingDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.

Songlin ZhangDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.ORCID https://orcid.org/0009-0004-3811-2099

Li LiangDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA. li.liang@bcm.edu.ORCID https://orcid.org/0009-0000-0259-5333

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sinonasal squamous cell carcinoma (SNSCC) comprises a heterogeneous group of tumors with emerging molecular subtypes. Human papillomavirus (HPV)-associated SNSCC is a distinct entity, although actionable genomic alterations beyond HPV-driven pathways remain underexplored. Distinguishing HPV-associated SNSCC from carcinoma ex inverted papilloma can be particularly challenging in limited biopsy specimens, as these lesions may appear morphologically similar. We report a case of HPV-associated SNSCC with concurrent FGFR3::TACC3 fusion and NOTCH1 p.C1416 stop-gain mutation.

Indexed as

Carcinoma, Squamous CellMicrotubule-Associated ProteinsPapillomavirus InfectionsParanasal Sinus NeoplasmsReceptor, Fibroblast Growth Factor, Type 3Receptor, Notch1Squamous Cell Carcinoma of Head and NeckHumansOncogene Proteins, FusionFGFR3 protein, humanMicrotubule-Associated ProteinsNOTCH1 protein, humanOncogene Proteins, FusionReceptor, Fibroblast Growth Factor, Type 3Receptor, Notch1TACC3 protein, humanFGFR3:TACC3HPV-associated squamous cell carcinomaNOTCH1Sinonasal tract

Identifiers

PMID42377805

DOI10.1007/s12105-026-01947-7

PMCPMC13319295

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.