Evidence map›Paper›PMID 42377622›Full record

Trial reportCancer causes & control : CCC2026

Knowledge of cancer genetics and attitudes about genetic counseling and testing: a randomized trial of the Know Your Risk intervention compared to conventional genetic counseling.

Mira L Katz, Patrick M Schnell, Paul L Reiter, Leigha Senter, Amber Aeilts, Christina Spears, Julia Cooper, Jordan Brown, Kate P Shane-Carson, Doreen M Agnese and 2 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cancer causes & control : CCC, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05325151 (A Randomized Controlled Trial Comparing a Genetic Counseling Patient Preference Intervention vs. Conventional Genetic Counseling for Women at Elevated Risk for Breast Cancer), which is not on this map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05325151 naactive not recruitingnot on this map

A Randomized Controlled Trial Comparing a Genetic Counseling Patient Preference Intervention vs. Conventional Genetic Counseling for Women at Elevated Risk for Breast Cancer

TypeinterventionalSponsorOhio State University Comprehensive Cancer CenterRan2022 to 2026Enrolled874ConditionsBreast CarcinomaArmsEducational Intervention, Genetic Counseling, Survey Administration
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mira L KatzDivision of Health Behavior and Health Promotion, College of Public Health, The Ohio State University, Columbus, OH, USA. mira.katz@osumc.edu.ORCID http://orcid.org/0000-0001-9791-7592
Patrick M SchnellDivision of Biostatistics, College of Public Health, The Ohio State University, Columbus, OH, USA.
Paul L ReiterDivision of Health Behavior and Health Promotion, College of Public Health, The Ohio State University, Columbus, OH, USA.
Leigha SenterComprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Amber AeiltsDivision of Human Genetics, Department of Internal Medicine, College of Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH, USA.
Christina SpearsDivision of Human Genetics, Department of Internal Medicine, College of Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH, USA.
Julia CooperDivision of Human Genetics, Department of Internal Medicine, College of Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH, USA.
Jordan BrownDivision of Human Genetics, Department of Internal Medicine, College of Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH, USA.
Kate P Shane-CarsonDivision of Human Genetics, Department of Internal Medicine, College of Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH, USA.
Doreen M AgneseComprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Amanda E TolandComprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Kevin SweetComprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine if the developed Know Your Risk (KYR) intervention is similar to conventional genetic counseling; we evaluated participants' knowledge of cancer genetics, breast cancer risk perception, attitudes about genetic counseling and testing, and satisfaction with genetic counseling.

methodsWomen (n = 866) who screened at elevated risk for breast cancer were randomized to the KYR intervention or conventional genetic counseling (2022-2024). The KYR intervention included a series of online pre-test educational videos, direct access to genetic testing, and patient preference for receiving post-test genetic counseling. Participants completed surveys at baseline and after genetic counseling and testing. Non-inferiority hypothesis testing compared the two participant groups.

resultsThe mean knowledge score (range 0-12) increased in both study groups from a baseline mean of 6.87 (standard deviation (SD) = 2.46) to 8.66 (SD = 2.16) for the KYR intervention and 8.56 (SD = 2.14) for conventional counseling. Additionally, statistical analyses suggest the non-inferiority of the KYR intervention for participants' accuracy of their breast cancer risk, attitudes about genetic counseling and genetic testing, and satisfaction with genetic counseling compared to participants randomized to conventional genetic counseling.

conclusionFindings support that the components included in the KYR intervention are non-inferior for cancer genetic knowledge, risk perception, genetic counseling and testing attitudes, and genetic counseling satisfaction among women who screen at elevated risk for breast cancer. By using the combination of components included in the KYR intervention, genetic counseling and genetic testing are more accessible, convenient, and patient-driven.

trial registrationClinicalTrials.gov Identifier: NCT05325151.

Indexed as

Breast NeoplasmsGenetic CounselingGenetic TestingHealth Knowledge, Attitudes, PracticeAdultFemaleGenetic Predisposition to DiseaseHumansMiddle AgedSurveys and QuestionnairesBreast cancerFemaleGenetic counselingGenetic testing

Identifiers

PMID42377622
PMCPMC13319172

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.