ArticleArchives of microbiology2026
Genetic potential of Limosilactobacillus fermentum 5.1.2 produces metabolite compounds with antioxidant activity.
Article in Archives of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Limosilactobacillus fermentum 5.1.2, a tempeh-derived probiotic candidate, was investigated through an integrated genome-to-cell approach to evaluate its antioxidant capacity. Whole-genome analysis using GhostKOALA (KEGG) and antiSMASH 7.0 identified a terpene precursor biosynthetic gene cluster and key genes involved in terpenoid backbone (idi, GGPS) and terpenoid-quinone biosynthesis (menA, menB, menC, menE, ubiE). LC-QTOF-MS of the cell-free supernatant extract putatively identified terpenoid and terpenoid-quinone metabolites, including linalyl propionate, geranylbenzoquinone, geranylhydroquinone, theasapogenol A, and momordol. This is consistent with the predicted biosynthetic pathways. The cell-free supernatant exhibited strong DPPH radical-scavenging activity (84.85-88.99% inhibition), while the extract showed antioxidant activity against DPPH and ABTS+ radicals with IC
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